Mononuclear cell cytotoxicity in rats with Walker 256 tumor

In the present study we characterized the cytotoxicity of Wistar rat mononuclear cells from 21 animals which received 10(6) Walker 256 tumor cells by the subcutaneous route. All animals developed the tumor. Cytotoxicity was studied 15 days after inoculation using spleen, thymus and lymph node T lymphocytes as well as macrophages from the peritoneal cavity. A Walker 256 tumor cell suspension and tumor cells in culture (YAC-1) were labelled with 51Cr and used as target cells, according to the Herberman technique and a gamma counter was used for counting. Anti-Walker cell cytotoxicity was significantly decreased in T lymphocytes from the spleen (9.6 vs 51.1 for the control) and thymus (11.5 vs 38.2 for the control), whereas no difference was observed for lymph nodes (41.2 vs 49.5 for the control) or macrophages (43.4 vs 46.3 for the control). Anti-YAC-1 cytotoxicity was significantly decreased in T lymphocytes from all lymphoid organs compared to control: 23.6 vs 42.8 for the spleen, 22.6 vs 41.1 for the thymus, 26.6 vs 42.1 for lymph nodes, and 27.1 vs 46.3 for macrophages. No correlation was observed between tumor weight, and anti-Walker cytotoxicity or anti-YAC-1 cytotoxicity.

Sarcoma granulocitico (cloroma): compressao de medula espinal e envolvimento testicular. / Granulocytic sarcoma (chloroma): spinal cord compression and testicular involvement

Sao apresentados dois casos de sarcoma granulocitico (cloroma) com compressao de medula espinal, um deles com massa tumoral do testiculo. A revisao da literatura mostra que embora que embora a infiltracao microscopia do testiculo na leucemia mieloide seja frequente, massas tumorais sao raramente observadas. Os dois casos apresentados foram diagnosticados durante o curso de leucemia mieloide aguda. Os autores enfatizam a necessidade de identificacao da doenca na fase pre-leucemica quando o diagnostico histopatologico pode apresentar dificuldade sem o uso de coloracoes especificas

Aspergilose pulmonar, aspectos anatomo-patologicos de um paciente portador de leucemia linfoide aguda. / Pulmonary aspergillosis, anatomo-pathological aspects of a patient with acute lymphoid leukemia

Este e o relato de um caso de um paciente com leucemia linfoide aguda em tratamento que desenvolveu uma pneumonia necrotizante bilateral por Aspergillus sp. Os autores comentam o aumento da incidencia de infeccoes oportunistas principalmente em pacientes portadores de neoplasias malignas particularmente linfomas e leucemias