Anaplastic large cell lymphoma presenting as sternal swelling

Lymphomas involving the sternum are very rare. We report a case of lymphoma presenting as lytic sternal lesion. A 14-year-old girl presented with history of painless swelling of central chest (sternum) of 3 months duration. Fine needle aspiration cytology from the site revealed anaplastic large cell lymphoma. It was confirmed by histopathology and immunohistochemistry. She underwent treatment with chemotherapy but succumbed to her illness after six months of treatment.

Biosynthesis of colloidal gold nanoparticles by Streptomyces sp. NK52 and its anti-lipid peroxidation activity.

Gold nanoparticles (Au-NPs) were synthesized from chloroauric acid using cell free supernatant of Streptomyces sp. NK52 grown in nutrient broth. These nanoparticles were synthesized by varying pH and temperature of the reaction mixture and chloroauric acid concentration. The nanoparticles were characterized by spectrometry, X-ray diffraction, Scanning electron microscopy and energy dispersive spectrometry. Au-NP ranged from 10-100 nm in size and exhibited a polydispersive nature with various shapes like rods, hexagons, triangles, spheres. The diffraction peaks at 2θ = 38.1◦ and 44.5◦ could be assigned to the (1 1 1) and (2 0 0) planes of a faced centre cubic (fcc) lattice of gold. Au-NP showed 47% inhibition of lipid peroxidation in vitro. To the best of our knowledge, this is the first report on the rapid biosynthesis of Au-NP using cell free supernatant of Streptomyces sp. and its evaluation for anti-lipid peroxidation.