ABSTRACT
Sickle cell trait is an inherited hematologic anomaly that affects 1 million to 3 million Americans and 8 to 10 percent of African Americans. It also affects other races like Hispanics, south Asians, Caucasians from southern Europe, and people from Middle Eastern countries. Evidence based estimations suggests that more than 100 million people worldwide have sickle cell trait. Unlike sickle cell disease, where two genes that cause the production of abnormal haemoglobin, individuals with sickle cell trait carry only one defective gene and typically live normal lives. Extreme conditions such as severe dehydration and high-intensity physical activity can lead to serious health issues, including sudden death, for individuals with sickle cell trait. We present a case of a young female with sickle cell trait who presented with overt retinopathy which is a rare phenomenon.