ABSTRACT
Acute myeloid leukemia [AML] with t[8;21][q22;q22] generating the AML1/ETO fusion gene on 8q22 is a distinct type of AML t[8;21] category [WHO]/AML-M2 [FAB], generally associated with a favourable prognosis. Variant additional chromosomal abnormalities are frequently reported. We report three adult cases of this category with unusual karyotype. Bone marrow cytogenetics of case no. 1: 45,X,-Y, t[8;21][q13;q22] with a novel breakpoint of chromosome 8 at [q13]. Case no. 2: 46,X,t[X;2][q22;q37],t[3;7][q21;q36],t[5;14][p15;q11],del[8][q22] a complex rearrangement without the involvement of chromosome 21. Case no. 3: 49,XX,+5, t[8;21][q22;q22], +16, +der[21]t[8;21][q22;q22] with additional der[21]. Endometrial in this case which was positive for myeloperoxidase [MPO] and CD117 conforming the AML infiltration. All are morphologically AML with t[8;21]. Relevant literature in cytogenetic of AML-M2 is reviewed. The molecular mechanism involved in unusual rearrangements and clinical significance of them are subjected for further studies
ABSTRACT
Toxoplasmosis is caused by an obligate intracellular protozoan parasite, Toxoplasma gondii. Most of the toxoplasma infections are asymptomatic or benign, but may cause severe or fatal consequences in immunodeficient patients, transplant recipients, and in the fetus. Transmission may occur by eating uncooked meat, contaminated vegetables, blood transfusion, organ transplantation, and across the placenta from the mother to the fetus. Antibodies to T. gondii may persist in the serum at high titers for years. We screened 784 Saudi blood donors using indirect hemagglutination test and 294 [37.5%] were found to be seropositive at different titers. The highest rate of seropositivity was found in the age group 21 to 30 years in males, and after 40 years of age, the presence of antibodies declined. Among females, the higher rate of seropositivity in the age group 18 to 20 years should be confirmed by further studies