ABSTRACT
The study aims to examine the Daboia russelli venom neutralization potential of the leaf extract of Ricirioccirpus indicus [Euphorbiaceae] at different dose levels. The acetone extract at two dose level [250 and 500 mg/kg] was studied for haemorrhagic, necrotizing and mast cell degranulation in rats and for its cardiotoxic and neurotoxic effects in isolated frog tissue. Administration of the acetone leaf extract at an i.p. dose level of 500 mg/kg significantly inhibited, in a dose-dependent manner, the Daboia nisselli venom-induced haemorrhagic, necrotizing and mast cell degranulation in rats and the cardiotoxic and neurotoxic effects in isolated frog tissue. Administration of the acetone extract also significantly reduced the Thiobarbituric acid reactive substance levels, enhanced the GST and GSH levels. The observations confirmed that the acetone leaf extract of Ricinoccirpus indicus possesses potent snake venom neutralizing properties