ABSTRACT
Effect of unique hemorrheologic agent pentoxifylline (PTX) was investigated on cyclosporine (CsA) induced nephrotoxicity in rats. Compared to saline control, CsA produced significant increase in blood urea and serum creatinine. Pentoxifylline treatment prevented the CsA-induced rise in blood urea and serum creatinine. Creatinine clearance (Ccr) and lithium clearance (Licr) was decreased with CsA. PTX treatment prevented the CsA-induced decrease in Ccr and Licr. Malondialdehyde (MDA) was increased with CsA compared to saline treated animals. PTX prevented the CsA-induced MDA rise. Kidney form CsA treated rat showed marked vacuolar degeneration of tubular epithelium with excess of microcalcification. Severity of the lesions was markedly reduced in rats treated with PTX plus CsA. The results indicate that PTX reduces CsA-induced renal toxicity in rats.
Subject(s)
Animals , Creatinine/blood , Cyclosporine/antagonists & inhibitors , Immunosuppressive Agents/antagonists & inhibitors , Kidney/drug effects , Male , Pentoxifylline/pharmacology , Rats , Rats, Wistar , Urea/blood , Vasodilator Agents/pharmacologySubject(s)
Carcinoma/complications , Female , Humans , Meningitis/etiology , Middle Aged , Ovarian Neoplasms/complicationsSubject(s)
Adult , Bronchial Neoplasms/pathology , Calcinosis/pathology , Carcinoma, Mucoepidermoid/pathology , Humans , MaleABSTRACT
Conjunctival impression cytology was used to study conjunctival ocular surface in 30 normal individuals in the age group of 20 to 60 years. The cytology was graded according to the classification of Nelson. Out of 30 subjects, 26 showed the features of Grade O (average age 28.33 years) and 4 showed grade 1 (average age 56.66 years). The method was very easy to perform, cheap and fast. The relationship of various cells to each other was maintained. This method can be used to study the conditions like trachoma, avitaminosis A and other disorders of conjunctival surface. It can be undertaken by a paramedical worker in an out patient clinic.
Subject(s)
Adult , Biopsy/methods , Conjunctiva/pathology , Conjunctival Diseases/pathology , Female , Humans , Keratoconjunctivitis Sicca/pathology , Male , Middle Aged , Trachoma/pathologyABSTRACT
Lymph-node aspirates performed over ten years numbering 1,555 showed 8.2 percent of metastatic tumors. Of these, only six percent were metastatic melanomas. Clinical diagnosis was made in three cases. Melanin in the cells made the diagnosis easy. But even in the absence of the pigment as in two amelanotic melanomas, the cytologic features were characteristic.