ABSTRACT
A multicenter study on the efficacy and tolerability of lacidipine in ambulatory Thai hypertensive patients was carried out in the Out-patient Department at Siriraj Hospital, Ramathibodi Hospital and Rajvidhi Hospital from October 1996 to July 1997. There were 46 patients who had mild to moderate hypertension (DBP>95 mmHg and <115mmHg). The enrolled-patients consisted of male : female = 20 : 26, age ranged between 23-69 years (51.98+9.49 years). The study showed that lacidipine 2-6 mg given once daily was able to normalize sitting BP (DBP < 90 mmHg) in 32 cases (69.4%). Among them, normalization of BP could be achieved by lacidipine 2 mg/d in 24 cases (52.2%), 4 mg/d in 4 cases and 6 mg/d in 2 cases. This study revealed that lacidipine in the therapeutic dose of 2-6 mg/d did not induce reflex tachycardia, metabolic derangement and importantly, did not produce any serious side effects.