ABSTRACT
Background: Urinary tract infection (UTI) is one of the most important global health issues, which has raised the morbidity and mortality rates in both the genders. Strategies that are proposed in the management of UTIs include use of empirical antibiotics with a broad spectrum of coverage. Urine specimen culture plays a pivot role to evaluate the organism responsible for the pathogenesis. Methods: This observational study was conducted at Vadodara comprised of 50 patients suffering from UTI. All the patients that included in the study were examined for side-effects during the entire period of the drug therapy. Clinical response was judged by subjective assessment for control of presenting symptoms. Results: Data were obtained from 50 patients. Garenoxacin was prescribed as a fi rst-line therapy to the patients with UTI. Four patients received the drug for 5 days and 44 patients received the drug for 7 days. Escherichia coli was the most common organism obtained from the urine culture, followed by Staphylococcus saprophyticus and Enterobacter species. Clinical cure/improved was established in 98% of cases. One case of therapy failure was reported. Negligible side-effects such as nausea, vomiting, and abdominal pain were reported. Conclusions: Garenoxacin with its superior yet differentiated pharmacodynamic and pharmacokinetic profi le involving low minimum inhibitory concentrations with high target site tissue concentrations defi nitely fi nds a merit for further evaluation. With superior safety profi le, excellent antimicrobial coverage and a convenient once a day dosing garenoxacin appears to improve the patient compliance.