Study of the effects of cimetidine upon rat testis

The effect of parenteral administered high [950 mg/kg] and low [150 mg/kg] dose of cimetidine on germinal epithelium of seminiferous tubules of testis in adult albino rats was studied. Cimetidine in high doses produces reduction in testicular weight and size, increase in tubular count per low power field and decrease in diameter and thickness of germinal epithelium of seminiferous tubules. The testicular changes observed could be due to toxic effect of drug on the body in general and testis in particular or it may have been mediated through hormones