ABSTRACT
Compare the anti ulcer effect of Methanolic Neem [Azadirachta indica, A Juss, Meliaceae] Leaf Extract [NLE] and Neem compound Nimolicin on gastric mucosa of albino rats. Azadiradione also called Nimolicine coded as NC has been studied for its anti insect effect but anti ulcer effect has never been studied. Experimental study. This study was carried out at the Pharmacy and Physiology Department of Baqai Medical College for duration of two years. Gastric ulcers in albino rats were induced in group-1 [check group] by a single oral dose of 1 ml 100% ethanol. After 24 hours the treatment was started. Group-2 was treated with oral administration of pea nut oil 1 ml/day for 5 days [control of the treated group]. Group-3 was treated with NLE [1 ml/day for 5 days] and Group-4 with NC 1% [1 ml/day for 5 days]. The healing effects of neem were compared to oral administration of anti ulcer drugs ranitidine [50mg/kg daily for 5 days] and omeperazole [2.5 mg/kg daily for 10 days]. Histopathology of the stomach was performed to confirm the presence or healing of ulcers. Ulcers were scored and indexed on the basis of histopathology. Ranitidine had the highest ulcer inhibition of 84%. NLE proved to be better than omeperazole by showing an ulcer inhibition of 82 % compared to 73% ulcer inhibition of omeperazole. NC showed least anti ulcer activity with an ulcer inhibition of only 69%. HPLC was performed to show the tissue concentration of NC, omeparazole and ranitidine showing their retention time, area and concentration compared to their controls. It is concluded that NLE proved to be better anti ulcer agent as compared to NC and can be used as an anti ulcer drug after clinical trials
ABSTRACT
To find relationship between ABO blood group and peptic ulcer [PU] in the ethnic population of Balochistan. An observational and prospective study. The study was carried at Bolan Medical College Complex Hospital Quetta for a period of one year. 60 peptic ulcer patients confirmed with video endoscope were included. ABO blood group was determined by slide test method. Out of 60 PU patients 54 were males and 6 females. 18 had blood group O, 24 had group B, 11 had AB and 7 had A blood group. 90% were Rhesus positive. O group was dominant [38.46%] in peptic ulcer patients with antral lesion. In patients having duodenal lesion, B group was prevalent [45.83%] Males were predominant sufferers [75%]. The poor and middle class patients were equally affected. The ethnic group Pathan were more affected [36.67%] compared to Baloch and Hazara. Antral lesions are dominant in O blood group peptic ulcer patients whereas duodenal lesion is common in blood group B. There is a high prevalence in Pathan males. Duodenal lesion is more prevalent compared to antral lesion