ABSTRACT
OBJECTIVE: To compare Oil of Evening Primrose and danazol,with respect to efficacy, rapidity of response and side effects in the treatment of mastalgia
STUDY DESIGN: It was quasi-experimental, purposive, non-probability sampling
PLACE AND DURATION: Conducted in surgical unit I and II departments Civil Hospital Karachi over a period of one year
METHODOLOGY: A total of 50 female patients with moderate to severe breast pain who visited the outpatient Surgical Department. All patients were assigned to two groups alternatively 25 in each group given Danazol, oil of evening primrose. Mastalgia in all the patients was gauged before and during the treatment according to the Cardiff, their level of mastalgia assessed and information sought about adverse effects of the drugs
RESULTS: The overall response with Danazol [CBSI 30%, CBS II 14%, CBSIII 6%] in contrast to low response with oil of evening primrose. The patient who was treated with Danazol showed distressing side effects whereas oil of evening primrose had fewer side effectsbreast pain score. All patients were seen at 8 and 12and 24 weeks
CONCLUSION: Danazol offered good pain control but with some undesirable side effects. Danazol should be used in moderate and severe mastalgia
ABSTRACT
Carcinoma gall bladder has a poor prognosis despite surgical resection of the tumour
-3 A prospective study was planned to evaluate carcinoma gall bladder according to its Clinicopathological presentation. Its frequency among gall bladder diseases was 5.21 percent with male to female ratio 1: 1.22. Average and median ages were 53.43 years and 55 years respectively. Peak age group was 5th decade. Three most common presenting complaints were right hypochondria! Pain [67.24 percent], vomiting [34.48 percent] and lump right hypochondrium [27.58 percent]. Most common macroscopic appearance was cauliflower like mass. Gall stones were associated with 39.65 percent cases. Most of the tumours were adenocarcinomas, majority in advanced histological grades. Glandular pattern was noticed in 27 cases and papillary pattern in 21 cases. Compared to developed countries our patients were more than a decade younger