Role of enterobactereacae in burn wound sepsis in Karachi

The over all prevalence of the Enterobacteriacae in present study was more than 50% in which the most prevalent organisms belongs to Proteus Spp. [38,3%] that followed by Enterobacter Spp. [22.4%]. The prevalence of E. coli and Kleb, Pneumoniae was 10%, Imipenem was the most effective [98%] drug against Enterobacieieacae. Ciprofloxacin was the second most effective [82%] drug. Amikacin and fourth generation Cefepirne were the third effective [>70%] drugs against these bacteria. Ciprofloxacin was the less effective [60-64%] drug against KIeb. pneumonia and E. coli than the rest of the isolates of Eiiterobactereacae. Arnikacin [49%] and Cefepime [44%] were less effective against Proteus Spp. More than 50% isolates were sensitive to Piperacillin, Gentamicin and Tobramycin. Amoxicillin and Augmentin were ineffective against these bacteria in this study

Multi drug resistant pseudomonas aeruginosa: a nosocomial infection threat in burn patients

Pseudomonas aeruginosa remains the leading pathogen causing burn wound infection. It is found as major colonizer of the burn wound because it thrives on moist burn wound surface and survives well in the hospital environment, once it is established, it can persist for months within a unit, and poses as multi drug resistant nosocomial infection threat for patients being treated there. The emergence of multi drug resistant Pseudomonas aeruginosa in burn wound is becoming a challenging problem in infection control programmes. A total of 44 isolates of Pseudomonas aeruginosa were recovered from burn patients. Most of them were resistant to multiple antibiotics. Their sensitivity against Imipenem was over all better than the other drugs i.e. 77.3%. Ciprofloxacin was the second most effective drug against this organism with a sensitivity of 54.5% while a 4th generation cephalosporin, Cefepime was effective against 22 [50%] isolates. About 30% Pseudomonas aeruginosa were sensitive to Amikacin. Aztreonam showed inhibitory activity against [6.8%] strains. Piperacillin activity was 18.2%. The efficacy of Cefutaxime was 4.5%. Chloramphenicol and Septran were 100% inactive against Pseudomonas infection while > 95% strains of Pseudomonas aeruginosa were resistant to Tobramycin

Acute and chronic toxoplasmosis; serological diagnosis in lymphadenopathy patients

Sera from 100 patients of lymphadenopathy were obtained and analyzed for antitoxoplasma IgG and IgM antibody by enzyme linked immunosorben assay [ELISA]. 36 patients were found to be seropositive, consisting of single sample of 26 patients and double samples of 10 patients. The antibody level showed that 10 patients were suffering from acute and 26 from chronic toxoplasmic infection. Regarding the analysis of seropositivity for age and sex distribution, it was found that in age group 2 1-30 years there was a significant difference [P<0.05] i.e. males dominated [61.53%] over the females [25%]