ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of Drynaria fortunei J. Smith naringin (DFSN) on proliferation and differentiation of human periodontal ligament cells (hPDLC).</p><p><b>METHODS</b>Cultured human periodontal ligament cells were treated with DFSN at different concentrations. Cell proliferation was determined by MTT method; cell differentiation was evaluated through the examination of alkaline phosphate (ALP) activities.</p><p><b>RESULTS</b>DFSN in a concentration ranged from 0.01 mu mol/L to 10 mu mol/L showed a promoting effect on proliferation of hPDLC (P< 0.05), and it also promoted ALP activities of hPDLC (P<0.05).</p><p><b>CONCLUSION</b>Drynaria fortunei J. Smith naringin can promotes the proliferation and differentiation of human periodontal ligament cells.</p>