ABSTRACT
<p><b>OBJECTIVE</b>To present 4 cases of hemophilic pseudotumor and to investigate the treatment outcome.</p><p><b>METHODS</b>Four cases of hemophilic pseudotumor were reviewed. The patients were treated by internal medicine combined with surgery and followed up for two years. The feature and diagnosis of the disease were analyzed and the treatment outcome was evaluated.</p><p><b>RESULTS</b>All of the 4 cases were misdiagnosed with a history of bleeding before operation. One patient was bleeding after biopsy without replacement therapy. One patient was presented with gingival bleeding and anaemia. The final diagnosis of hemophilia A in all the 4 cases was confirmed by the blood test (VIII deficiency). After infusion of factor VIII, operation was performed on all cases. There was no recurrence after two years of follow-up.</p><p><b>CONCLUSIONS</b>It should be aware of the rarely encountered disease which is prone to be misdiagnosed. Under factor-deficient replacement therapy, surgical management is the most effective way in preventing from bleeding and avoiding progressive expanding of pseudotumor.</p>