ABSTRACT
Objective: To establish the optimal prescription and technique for preparing zedoary turmeric oil (ZTO) microcapsule. Methods: Using the diameter of microcapsule, microcapsule form, and embedding rate as indexes, the ratio of capsule materials, ratio of core material and capsule material, content of dry matter, content of additive, speed of emulsifying, time of emulsifying, temperature of wind and the power of feed were studied. Results: The optimal conditions for preparation of spray drying of ZTO microcapsule were as follows: gum Arabic-gelatin (1.0∶1.0), core material-capsule material (0.30∶1.0), PEG6000 content of 2%, dry matter content of 20%; The optimal technique was as follows: The emulsion speed was 10 600 r/min, emulsifying time was 9 min, temperature of inlet air was 160 ℃, and feed power was 6%. According to the optimum experimental conditions, the microcapsule was round relatively, the surface density was well, the particle size of microcapsule appeared uniform distribution, most concentrates in 1.0—2.5 μm, and showed good normal distribution, the average particle size was 1.913 μm, the embedding rate could reach 75.4%. Conclusion: This experiment can increase the stability of ZTO, cover up its bad smell, and raise the utilization ratio of drugs, the repeatability is also good.