ABSTRACT
Objective :To study therapeutic effect of irbesartan combined amlodipine on aged patients with diabetes mellitus complicated hypertension .Methods : A total of 94 aged patients with diabetes mellitus complicated hypertension ,who were treated in our hospital from Feb 2015 to Aug 2016 ,were selected .Patients were randomly and equally divided into amlodip‐ine group (received amlodipine based on routine treatment ) and combined treatment group (received irbesartan based on amlodipine group) ,both groups were treated for 12 weeks.Levels of blood pressure : SBP , DBP ,fasting plasma glucose (FPG) ,fasting insulin (FINS) and serum 25‐hydroxyl vitamin D3 [25‐(OH) D3] before and after treatment ,total effec‐tive rate and incidence rate of adverse reactions were observed and compared between two groups .Results : Total effective rate of combined treatment group was significantly higher than that of amlodipine group (91.49% vs.74.47%) , P＝0.028. Compared with before treatment ,after treatment ,there were significant reductions in levels of SBP ,DBP and FINS and significant rise in serum 25‐(OH) D3 level in two groups ,and significant reduction in FPG level in combined treatment group , P＝0.001 all.Compared with amlodipine group after treatment ,there were significant reductions in lev‐els of SBP [ (144.02 ± 11.24) mmHg vs.(129.75 ± 10.07) mmHg] ,DBP [ (85.20 ± 7.27) mmHg vs.(75.72 ± 8.13) mmHg] ,FPG [ (7.14 ± 0.47) mmol／L vs.(6.72 ± 0.51) mmol／L] and FINS [ (19.28 ± 3.24) μU／ml vs.(16.18 ± 2.39) μU／ml] ,and significant rise in serum 25‐(OH) D3 level [ (26.37 ± 3.87) μg／L vs.(32.48 ± 4.22) μg／L] in combined treatment group ,P＝0.001 all.There was no significant difference in incidence rate of adverse reactions between two groups ,P＝0.712. Conclusion : Irbesartan combined amlodipine possesses significant therapeutic effect on aged patients with diabetes mellitus complicated hypertension .It can significantly and effectively control blood pressure ,improve glucose metabolism with good safety ,which is worth extending .