ABSTRACT
Objective To explore the diagnostic value of fine needle aspiration combined with molecular markers in the diagnosis of thyroid carcinoma .Methods A total of 48 cases with thyroid nodules form 2011 to 2015 were selected as objects in this re-search ,samples collected after receiving operation were detected by fine needle aspiration ,all patients suspected of malignant tumor were conducted immunohistochemical CD147 staining analysis ,if the result of CD147 was positive ,it could be judged to be malig-nant ,and the result was compared with pathological results .Results CD147 staining results showed 28 patients with negative re-sults ,pathological examination after operation diagnose that 6 cases was malignant ,22 cases was benign .The difference of CD147 staining expression between benign and malignant nodules was statistically significant (P<0 .05) .There were significant differences between the result of CD147 expression and calcification nodules and lymph nodes metastasis of B-scan ultrasonography(P<0 .05) . The differences on sensitivity ,positive predictive value and accuracy between B-scan ultrasonic and the fine needle aspiration(FNA) and fine needle aspiration combined with molecular markers of comparison were statistically significant (P<0 .01) .Conclusion The molecular marker CD147 is an important marker for the diagnosis of thyroid tumor cytology ,and the detection rate of thyroid cancer could be significantly improved by fine needle aspiration cytology combined with CD 147 histochemical analysis .
ABSTRACT
Objective To explore the diagnostic value of fine needle aspiration combined with molecular markers in the diagnosis of thyroid carcinoma .Methods A total of 48 cases with thyroid nodules form 2011 to 2015 were selected as objects in this re-search ,samples collected after receiving operation were detected by fine needle aspiration ,all patients suspected of malignant tumor were conducted immunohistochemical CD147 staining analysis ,if the result of CD147 was positive ,it could be judged to be malig-nant ,and the result was compared with pathological results .Results CD147 staining results showed 28 patients with negative re-sults ,pathological examination after operation diagnose that 6 cases was malignant ,22 cases was benign .The difference of CD147 staining expression between benign and malignant nodules was statistically significant (P<0 .05) .There were significant differences between the result of CD147 expression and calcification nodules and lymph nodes metastasis of B-scan ultrasonography(P<0 .05) . The differences on sensitivity ,positive predictive value and accuracy between B-scan ultrasonic and the fine needle aspiration(FNA) and fine needle aspiration combined with molecular markers of comparison were statistically significant (P<0 .01) .Conclusion The molecular marker CD147 is an important marker for the diagnosis of thyroid tumor cytology ,and the detection rate of thyroid cancer could be significantly improved by fine needle aspiration cytology combined with CD 147 histochemical analysis .