Preparation of paeonol-beta-cyclodextrin inclusion complex loaded colon specific delivery tablets / 中国中药杂志

<p><b>OBJECTIVE</b>To prepare paeonol-beta-cyclodextrin inclusion complex (Pae-beta-CYD) loaded colon-specific release tablets.</p><p><b>METHOD</b>The core tablets were prepared with the mixture of Pae-beta-CYD inclusion complex, peotin and calcium acetate, and coated with ethanolic solution of Eudragit S100. The effects of coating weight, amount of plasticizer, curing time and temperature on the release of drug from tablets were investigated in vitro.</p><p><b>RESULT</b>About 5-6 h retarded release of paeonol in the dissolution media of pectinase or rats colon contents were obtained by 12% coating weight gain and 20% Dibutyl phthalate (DBP) was used as plasticizer, and subsequently curing the tablets at 45 degrees C for 12 h.</p><p><b>CONCLUSION</b>Pae-beta-CYD loaded colon-specific release tablets showed pH environment and enzyme dependant release properties.</p>

Preparation and in vitro release of ginkgo biloba extract sustained-release tablets / 中国中药杂志

<p><b>OBJECTIVE</b>To prepare ginkgo biloba extract (GBE) sustained-release tablets and observe its in vitro release profile.</p><p><b>METHOD</b>GBE sustained-release tablets were prepared by direct compression method using sodium carboxymethylcellulose (CMC-Na) and hydroxypropyl methylcellulose HPMC) as matrix excipients. Based on the result of single-factor selecting experiment, the formulations and preparation process were optimized through orthogonal design, and release difference of tablets was evaluated with similarity factor (f2).</p><p><b>RESULT</b>The ratio of HPMC and CMC-Na, the viscosity of HPMC and the different types of the diluents had pronounced effect on the release of GBE sustained release tablets, although the hardness and weight difference of tablets did not show notable influences.</p><p><b>CONCLUSION</b>GBE sustained-release tablets that prepared by using the mixture of HPMC and CMC-Na display constant release profile in 12 h.</p>