ABSTRACT
BACKGROUND: A number of clinical trials addressing olfactory ensheathing cells for the treatment of chronic spinal cord injury have been conducted in the world, but the efficacy and safety are still controversial. OBJECTIVE: To evaluate the safety and efficacy of olfactory ensheathing cell transplantation for chronic spinal cord injury, and to further compare its short-and long-term efficacy. METHODS: PubMed, Cochrane Library, EMBASE, CNKI and WanFang databases were searched at July 23, 2018 for retrieval of clinical trials addressing olfactory ensheathing cells in the treatment of chronic spinal cord injury. Types and cases of adverse events during the safety trial should be recorded in detail. In the enrolled studies, American Spinal Injury Association scale was used to assess the motor, light touch, and pinprick scores of spinal cord injury patients before and after cell transplantation. The follow-up time was recorded. Systematic evaluation of efficacy data was performed using Review Manager 5.3. RESULTS AND CONCLUSION: Both short-and long-term follow-up data showed that the neurological function of patients was significantly improved after olfactory ensheathing cell transplantation (P < 0.05) , and the results were homogeneous (I2 < 50％ and P> 0.1). However, the long-term efficacy was not as good as the short-term efficacy, which may be related to chronic rejection and olfactory ensheathing cell survival. The overall adverse event rate was 8.99％, and no complications associated with olfactory ensheathing cells occurred. These findings show that olfactory ensheathing cell transplantation is effective and safe in the treatment of chronic spinal cord injury, but it is still necessary to explore more minimally invasive approaches to reduce surgical complications. In addition, a large number of high-quality experiments and clinical trials are warranted to confirm factors affecting the long-term efficacy of olfactory ensheathing cell transplantation.
ABSTRACT
BACKGROUND: A number of clinical trials addressing olfactory ensheathing cells for the treatment of chronic spinal cord injury have been conducted in the world, but the efficacy and safety are still controversial. OBJECTIVE: To evaluate the safety and efficacy of olfactory ensheathing cell transplantation for chronic spinal cord injury, and to further compare its short-and long-term efficacy. METHODS: PubMed, Cochrane Library, EMBASE, CNKI and WanFang databases were searched at July 23, 2018 for retrieval of clinical trials addressing olfactory ensheathing cells in the treatment of chronic spinal cord injury. Types and cases of adverse events during the safety trial should be recorded in detail. In the enrolled studies, American Spinal Injury Association scale was used to assess the motor, light touch, and pinprick scores of spinal cord injury patients before and after cell transplantation. The follow-up time was recorded. Systematic evaluation of efficacy data was performed using Review Manager 5.3. RESULTS AND CONCLUSION: Both short-and long-term follow-up data showed that the neurological function of patients was significantly improved after olfactory ensheathing cell transplantation (P < 0.05), and the results were homogeneous (I2 < 50％ and P> 0.1). However, the long-term efficacy was not as good as the short-term efficacy, which may be related to chronic rejection and olfactory ensheathing cell survival. The overall adverse event rate was 8.99％, and no complications associated with olfactory ensheathing cells occurred. These findings show that olfactory ensheathing cell transplantation is effective and safe in the treatment of chronic spinal cord injury, but it is still necessary to explore more minimally invasive approaches to reduce surgical complications. In addition, a large number of high-quality experiments and clinical trials are warranted to confirm factors affecting the long-term efficacy of olfactory ensheathing cell transplantation.
ABSTRACT
Objective To analysis the influence of health management intervention on blood glucose control for 2 diabetic, discusses in view of the diabetic not good life style practice the effective health management measure. Methods Reviewed the diagnosised 2 diabetic examples (1152) from March,2003 to July,2007 by healthy physical examination and the physical examination materials, including the biochemistry items like fasting blood glucose (GLU), Glucosylated hemoglobin (HbAlc) and the questionnaires about each patient's formerly body activity, the diet and the medical compliance etc. Established the standard,carried on the appraisal. According to the above, the life style relative good 283 examples (A group) and the bad 869 examples (B group) the patient will integrate the cohort, carried on the cohort study, analysised the relations between life style and diabetes controll effectiveness; At the same time, compared the biochemistry results between the non-managed (C group) and the managed (D group) after by meanse of a year strengthened health management intervention (diet, movement, medical compliance, health education etc.) on the 241 example patients. Results The GLU and HbAlc control satisfaction rate of the life style relative good group's (A group) respectively is 60. 1% and 56. 5%, obviously surpasses the life style bad group's (B group) 49.0% and 45. 5% (X2 = 10.44 and 11.05, P<1.01) ; The unscientific life style is diabetes GLU and the HbAlc control not satisfactory the dangerous fact (RR = 1.28 and 1.25) ; After carries on the life style strengthening intervention for a year (D group), the nutrition and the movement knowledge awareness rate (63.5%) is obviously higher than the before management (C group) (25.7%), the difference has statistics significance (X2=4.51, P<0.05), after and before the strengthening life style management intervention, GLU and HbAic control satisfaction rate is respectively 61.8% ,64. 3% and 58.5%, 47.8%, the difference has statistics significance (X2=7.94 and 4.18, P<0.01 and 0.05) Conclusions The life style has a close correlation with the effectiveness of 2 diabetes blood glucose control, the health management intervention can raise the patient's good life style, helps the patient to obtain satisfaction the blood glucose control effectiveness.