Rad17 and its significance in tumor / 国际肿瘤学杂志

Radl7 is an early replication checkpoint protein which sensing DNA lesions during DNA replication and halting progression ofreplication fork in cell cycle.It plays an important role in insuring the integrality and stability of DNA.Recent researches reveal that its functional defect and high expression may correlate with cell carcinogenesis and progression of carcinoma.