ABSTRACT
Differentiated thyroid carcinoma (DTC) cells can produce loss of differentiation in the progress of cancer development,especial of metastasis.The morphology and function of loss of differentiation DTC cell both generate degenerative changes,resulting in the reduction or loss of iodine uptake of the radioactive,which make radioactive iodine(131Ⅰ) treatment and thyroid hormone suppression therapy inefficient on treating DTC.Retinoic acid(RA) is a biologically active metabolite of vitamin A,which plays an important role in many cell morphology,degree of differentiation and proliferation process.Studies have shown that the application of RA can induce the loss differentiation of DTC redifferentiation,make its to reverse for functional thyroid organization.It’s important to produce the clinical significance,which can improve the cure rate and survival rate of the DTC patients.