ABSTRACT
Pancreatic ductal adenocarcinoma is a kind of neoplasms with poor neovascularization and rich matrix,which limited the delivery of cytotoxic drugs to cancer cells.Nanocarriers delivery of cytotoxic drugs to treat pancreatic cancer would overcome those biological barriers,and promote drug delivery efficiency.The designation of high targeting of pancreatic cancer cells nanoparticles and smart drug delivery system have been the key factors to improve nanocarriers' drug delivery efficiency.Here,we report the latest advanced researches in this field,including passive targeting design,active targeting design and response to the release of drug delivery design.
ABSTRACT
Endothelin (ET) is a peptide released by vascular endothelial cells. Except for the potent vasoconstrictor function it plays an important physiological role in tissue differentiation and development, cell proliferation and hormone production. Investigation of the role of ET axis in a variety of tumors such as prostatic, cervical, breast carcinoma has provided evidences of its importance in cancer, recently. Data suggest that multiple functions of the ET axis have associations with mitogenesis, apoptosis inhibition, angiogenesis, and activation of proto-oncogene. The ET axis relates to invasiveness, osteoblast function, and metastatic cancer pain in advanced prostate cancer.