ABSTRACT
Natural products have been the source of most of the active ingredients in medicines. Natural medicines play an important role to keep the healthy of mankind in history even today. Chemistry of natural medicine is a scientific branch of exploration chemical composition in natural medicine using the modern science and technology and has captured the more and more attention of scientists. The development in chemistry of natural medicine and its relationship of other related disciplines are summerized in this paper.
ABSTRACT
Ocean is a unique and excellent resource that provides a diverse array of intriguing natural products. Marine natural products have demonstrated significant and extremely potent biological activities and have captured the attention of natural products chemists in the past few decades. It is increasingly recognized that a wealth of fascinating natural products and novel chemical entities will play a dominant role in the discovery of useful leads for the development of pharmaceutical agents and provide useful probes to lead to breakthroughs in a variety of life-science fields. This article focused on the research progress of chemistry of marine natural products in recent five years.
Subject(s)
Animals , Humans , Alkaloids , Chemistry , Pharmacology , Anti-Infective Agents , Chemistry , Pharmacology , Antineoplastic Agents , Chemistry , Pharmacology , Aquatic Organisms , Chemistry , Biological Products , Chemistry , Pharmacology , Macrolides , Chemistry , Pharmacology , Marine Biology , Marine Toxins , Chemistry , Pharmacology , Molecular Structure , Peptides , Chemistry , Pharmacology , Steroids , Chemistry , Pharmacology , Terpenes , Chemistry , PharmacologyABSTRACT
<p><b>OBJECTIVE</b>To study the non-taxoids in the leaves of Taxus mairei.</p><p><b>METHOD</b>The chemical constituents were isolated by chromatography and identified by spectral data.</p><p><b>RESULT</b>Five compounds, taxamairin A (1), taxamairin B (2), sciadopitysin (3), ( - ) matairesinol (4), ponasterone A (5) were isolated and identified.</p><p><b>CONCLUSION</b>Compounds 3-5 were isolated from this plant for the first time, compounds 1 and 2 were isolated from the leaves of T. mairei for the first time.</p>
Subject(s)
Biflavonoids , Chemistry , Diterpenes , Chemistry , Ecdysterone , Chemistry , Furans , Chemistry , Lignans , Chemistry , Plant Leaves , Chemistry , Plants, Medicinal , Chemistry , Taxus , ChemistryABSTRACT
<p><b>OBJECTIVE</b>To study the chemical constituents in the heartwood of Taxus cuspidata.</p><p><b>METHOD</b>Silica gel column chromatography, preparative HPLC and preparative TLC were used to isolate and purify the chemical constituents; 1H- and 13C-NMR spectroscopic methods were used for structural identification.</p><p><b>RESULT</b>Ten compounds, taxinine (1), taxusin (2), beta-sitosterol (3), 1 beta-hydroxybaccatin I (4), 2alpha, 5alpha, 10beta-triacetoxy-14beta-(2'-methyl) butanoyloxy-4 (20), 11-taxadiene (5), 2alpha, 5alpha, 10beta-triacetoxy-14beta-(2'-methyl-3'-hydroxy-butanoyloxyl-4 (20), 11-taxadiene (yunnanxane) (6), 9alpha, 10beta, 13alpha-triacetoxy-5alpha-cinnamoyltaxa-4 (20), 11-diene (7), 2-deacetoxytaxinine J (8), taxezopidine G (9), 2alpha, 7beta, 9alpha, 10beta, 13alpha-pentaacetoxyl-taxa-4 (20), 11-dien-5-ol (5-decinnamoyltaxinine J) (10), were isolated and identified from the heartwood of T. cuspidata.</p><p><b>CONCLUSION</b>Three taxanes, 1 beta-hydroxybaccatin I (4), 2alpha, 5alpha, 10beta-triacetoxy-14beta-(2'-methyl-3'-hydroxy-butanoyloxy)-4 (20), 11-taxadiene (yunnanxane) (6), and 2alpha, 7beta, 9alpha, 10beta, 13alpha-pentaacetoxyltaxa-4 (20) , 11-dien-5-ol (10), were obtained from this plant for the first time.</p>
Subject(s)
Diterpenes , Chemistry , Heterocyclic Compounds, 4 or More Rings , Plant Stems , Chemistry , Plants, Medicinal , Chemistry , Taxoids , Chemistry , Taxus , ChemistryABSTRACT
<p><b>OBJECTIVE</b>To study the chemical constituents in seeds of Taxus mairei.</p><p><b>METHOD</b>Preparative HPLC, TLC and spectroscopic analyses were used to isolate and elucidate the chemical constituets in the plant.</p><p><b>RESULT</b>Seven taxane diterpenoids were isolated from the seeds of T. mairei and identified as taxinine A(1), 9-deacetyltaxinine(2), 9-deacetyltaxinine E(3), 2-deacetyltaxinine(4), taxezopidine G(5), 2-deacetoxytaxinine J(6), 2-deacetoxytaxuspine C(7).</p><p><b>CONCLUSION</b>Except compounds 5,6, all the compounds were obtained from seeds of this plant for the first time.</p>