ABSTRACT
Seventy dogs were irradiated -with 300. 325, or 350 rad of gamma rays from a 60Co sourse. Half of them were used as controls and the other 35 animals were divided randomly into four groups and were experimentally treated with different regimes.In the first group there were 9 treated, animals and an equal number of control animals 5 all the animals were irradiated with 300 rad. The treatment consisted of a blood transfusion on the 16th day after radiation exposure as well as several antibiotics and other medications. 8 out of the treated animals and one of the controls survived the gamma irradiation.In the second group, ten animals were exposed to 350 rad and 8 to 325 radand they were divided equally into treated and control groups. In spite of early use of blood transfusion and antibiotics, all the treated animals as well as those of the control group died of severe mycotic infections.In the third group, 325 rad was given to the dogs. All 7 dogs of the controls died and two out of the 7 treated dogs survived. The treatment was the same as that of the first group but no blood transfusion was used.In the fourth grou'p?ten animals were irradiated with 350 rad and another ten with 325 rad. They were divided equally into control and treated groups. All the ten controls died. The treated group was given the same treatment as the first group. In addition, tetracycline was given in case there was fever in 'the critical phase of the sickness, and the dosage of tetracycline was doubled whenever fever persisted or recurred. All the treated animals survived.Early blood transfusion was found to be better in its therapeutic effect than late transfusion.
ABSTRACT
Thirty-four dogs were inflicted with blast injury from a shock tube with a diameter of 348 mm. The peak value of the overpressure was 1.05~1.33kg/ cm2, the effective time of the overpressure 40~45 milliseconds, and the speed of the blast wave 473~509m/s. There were 11 dogs (32.4%) with very severe damage, 5 (14.7%) with severe damage, 17 (50%) with moderate damage and 1 with mild damage. The peak value and the effective time of the overpressure were the decisive factors to determine the severity'of the damage, and the posture of the animal at the time of blast impact might also be important. The sensivity of different organs to the blast wave was not uniform, it was related to the position, size, degree of dissociation, and structural characteristics of the organ concerned. The order of the sensitivity of various organs, from highly to less sensitive, could be arranged as follows; the audotory apparatus, the liver, the lungs, the spleen, the heart, the urinary bladder, and the kidneys. It is suggested that in diagnosing a case of blast injury, an examination of the audotory apparatus and a total and differential white count be of value.The pathological changes caused by the blast wave from a shock tube were similar to those caused by nuclear explosion in nature but milder in degree since the effective time of the overpressure of the shock tube wave was shorter. The chief causes of early death of the animals with blast injury were massive hemorrhage and cranial injury.
ABSTRACT
The effects of a chemical radioprotector,WR-2721,on peritoneal macrophages were observed in Kunming strain mice.which were randomized into WR-2721 group and normal control group.The mice of the 2 groups were similarly treated except that each of those of the WR-2721 group received an intramuscular injection of 10 mg WR-2721.The phagocyte-digestive function of the macrophages were observed after glycogen activation and chicken red blood cell ingestion.It was found that in the WR-2721 group,as compared with those of the normal control,juvenile macrophages were significantly reduced(P