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Objective To investigate the expression of tumor metastasis associated protein I (MTA1) in esophageal cancer tissue and its relationship with clinicopathological features and 3-year survival rate.Methods Ninety-six postoperative pathological samples of esophageal cancer and 40 samples of paracancerous tissue conforming to the inclusion standard collected by the pathological department of this hospital from January 2010 to December 2012 were selected and performed the immunohistochemical staining.Then the relationship between MTA1 protein expression with the clinicopathological features and long term survival rate was analyzed.Results The MTA1 protein expression rate in the esophageal cancer tissueswas 73.96％,which was significantly higher than 2.50％ in paracancerous tissues (P＜0.05);esophageal cancer tissues MTA1 protein expression mainly had significant correlation with TNM stage and lymph node metastasis(P＜0.05);the 3-year survival rate in the patients with esophageal cancer tissue MTA1 protein positive expression was 33.80 ％,which was significantly lower than 60.00 ％ in the patients with MTA1 protein negative expression (P＜0.05);the long-term survival rate in the patients with esophageal cancer had significant relationship with TNM staging and MTA1 protein expression (OR=1.638,OR=1.433,P＜0.05).Conclusion MTA1 protein is highly expressed in esophageal cancer tissue,and has the relationship with TNM stage and lymph node metastasis,MTA1 protein high expression is an independent risk factor for the prognosis in the patients with esophageal cancer.
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@# ObjectiveTo observe the effect and security of Batroxobin vein injection on patients with diabetes mellitus and acute cerebral infarction.Methods66 patients with diabetes mellitus and acute cerebral infarction were treated with Batroxobin vein injection and assessed with the scale of neurological deficit before treatment and at 3rd and 6th day after treatment.At the same time the coagulant function and the count of blood platelet were measured.ResultsAfter treatment,the concentration of fibrinogen in blood plasma of patients decreased and scores of neurological deficit assessment improved both significantly(P<0.001).The total validity of Batroxobin vein injection was 93.9%.No side actions of drug were found.ConclusionBatroxobin vein injection can be used as a therapeutic method of dissolving thrombus in patients with diabetes mellitus and acute cerebral infarction in early stage.
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Objective: To establish the database on typing of Chin es e condyle head by skull base position X ray analysis. Methods: 51 Chinese volunteers (male 33, 65 condyles; female 18, 35 condyles) accep ted skull base position X ray inspection. Then the 100 condyle images were ana lyzed and the contribution of the types among sexes and sides were also analyz ed. Results: The types of condyle were divided into A,B,C, D,E(E1,E2) and F(F1,F2).Among all condyle types, type A was accounted for 41.0% , while type F1 only 1%. The contribution of the types between left and right si des was almost the same. 51% (26 pairs) of the two condyles in the same person share the same type, the other 23 pairs of condyles were in different types (mal e 39.1 %, female 60.9%). Conclusion: The morphology typ ing of condyle heads by skull base position X ray analysis may be reference to clinical application.
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Objective: To analyse the acuracy of color doppler ultrasound examination in the measure- ments of blood vessels in tissue flaps. Methods: 110 pieces of associated blood vessel in tissue flaps in 64 cases were measured with color doppler ultrasound examination before operation. The quality of blood vessel, its diameter, blood stream filling, the vascular pedicle length and its depth were measured. The results were checked and compared with the findings in operation. Results: Of all 110 pieces of associated blood vessel evaluated by doppler, the accurate ratio confirmed by the finding in operation was 100%. The inner diameter of 38 pieces of blood vessel measured in operation was coincident with that measured by doppler before operation, or with little difference. Conclusion: The color doppler ultrasound examination is a reliable method for evaluating the blood vessel both of the donor and host areas in maxillofacial reconstruction surgery with tissue flap.
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objective: To evaluate the embolization effect of 5 Fu gelatin microsphere(FGM) in oral and maxillofacial region.Methods: FGM was prepared with drug load of 12% and encapsulation of 85%. After irridiated with 60 Co, FGM was suspended into 76% of meglumine diatrizoate, and then perfused into external maxillary artery and lingual artery in 8 dogs under X ray observation. 4 dogs were used in each artery embolization. Blood flow velocity and volume in the arteries were tested at different time after embolization; all the data were analyzed statistically. The sections of embolized tissue at different time were examined microscopically. Results: Before and 1 h, 48 h and l month after ombolization the blood flow volume(ml/min) in external caroted artery was 43?5.0, 31.0?4.5, 26.5?4.0 and 35.0?30; that in external maxillary artery 5.0?1.5, 0.5?1.0, 2.5?1.0 and 3.0?1.5; in ligual artery 3.5?1.0, 0.5?0.5, 0 and 0; in internal maxillary artery 17.0?4.0, 19.5?4.0, 19.0?4.5 and 21.0?3.5, respectively. Stuff of the cavity of the corresponding arteries by FGM were found with histological examination. Conclusion: FGM can embolize artery completely.
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Objective:To evaluate 2D ultrasonography(2DUS), color Doppler flowing imaging(CDFI) and color Doppler energy (CDE) in the differential diagnosis of benign and malignant tumors of salivary glands.Methods:According to the characters of 2DUS and CDFI examination, benign and malignant tumors in 142 cases of salivary glands were distinguished. The results of ultrasound examination and postoperative biopsy were checked and compared. Meanwhile the same tumor's blood flow information and hemodynamics index were compared. Results:In 2DUS examination, the inter echo and post echo of benign and malignant were different. In CDFI examination, the blood flow form could be displayed clearly. Besides Warthin tumors, the blood supply ranking of benign tumors was usually levelⅠor Ⅱ-(78.7%), and that of malignant tumors was levelⅡ+ or Ⅲ(80.0%). The artery's peak systolic velocity(PSV) of malignant tumors was higher than that of benign tumors. The rates(%) of sensitivity, specificity,accuracy,false negative, false positive, positive predicting and negative predicting of 2DUS were 70.2,87.4,81.7,29.8,12.6,73.3 and 85.6,those of CDFI 80.9,65.2,70.4,19.1,34.7,53.0 and 87.3,those of the integrated usage of ultrasonic methods 89.3,90.5,90.1,10.6,9.5,82.4 and 94.5 respectively.Conclusion:With the integrated usage of ultrasonic methods, higher accuracy of differential diagnosis for benign and malignant salivary glands tumors may be obtained.
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Objective: To review the effect of the treatment of maxillofacial and cervical tumor with external cervical atery intervention technique(ECAI). Methods: 92 cases of maxillofacial and cervical tumor were treated with ECAI. Therapeutic embolization was conducted in 30 cases, arteroy perfusion in 42 and opacification in 20. The patients were cared psycologically befor operation, monitored carefully in operation, especially for contrast medium responsing, antitumor drug responsing,embolisming responsing, etc. Results: Permanent embolization was achieved in 5 cases of hemangioma, bleeding was reduced by 75% in 25 cases treated with subsidiary embolization, local and general condition was improved in 32 patients with malignant tumor by perfusion of antitumor drug. Accuration of angiography was achieved in 93% of the cases. Complications were found in 7 cases and cured after treatment but in 1 who died of cerebrovascular disease. Conclusion: Perioperative monitoring is important to eliminate complications of ECAI.