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Study on stability of Caitong Tablets with the constant temperature accelerated test has been carried out. Using the flavone component in Caitong Tablets as an index,their content was determined. It was predetermined that the shelf life was 4. 11 years.
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AIM:To research the stability of Compound Wurenchun Soft Capsule in 18 months. METHODS:TLC and HPLC methods were used.Schizandrol A was separated on a ODS-C_(18) column(Lichrospher ODS-C_(18),(4.6 mm?250 mm),) using methyl alcohol-water (65∶35) as the mobile phase,detected at 250 nm.The velocity of flow was 1.0 mL/min.Paeoniflorin was separated on a ODS-C column(Lichrospher ODS-C_(18),4.6 mm?250 mm),using acetonitrile-water-phophoric acid(15∶85) as the mobile phase,detected at 230 nm,the velocity of flow was 1.0 mL/min. RESULTS:There was a good linear relationship at the range of 0.04 mg/mL-0.64 mg/mL for schizandrol A(r=0.999 8).The average recovery of schizandrol A was 98.76%(n=6,RSD=1.18%).There was a good linear relationship at the range of 0.05 mg/mL-0.80 mg/mL for paeoniflorin(r=0.999 9).The average recovery of paeoniflorin was 97.93%(n=5,RSD=1.68%). CONCLUSION:In 18 months,the quality of Compound Wurenchun Soft Capsule is steady.
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OBJECTIVE:To get clear idea about the current situation and future trend of use of antidepressants METHODS:By using the methods of order of sum of money and DDDs,the antidepressants used in our hospital in years 1998～2001 were analysed RESULTS:The annual sum of money and DDDs of antidepressants were increasing and the sum of money and DDDs of antidepressants used in 2001 were 3 69 times and 2 14 times as much as those in 1998,respectively Although the proportion of sum of money of tricyclic antidepressants(TCAs) was lower than that of new type antidepressants(NTAs),Clomipramine hydrochloride and Doxepin belonging to TCAs were in the first five places in order of DDDs during the past four years Because of the low price and less side effect,the position of NTAs in therapy of depressions was increasing CONCLUSION:TCAs are still the first choice in therapy of depressions The prospects of NTAs will be wide and bright It is important to speed up the development of Chinese materia medica in therapy of depressions