ABSTRACT
Objective To investigate the effects of pyrroloquinoline quinone(PQQ) on the hippocampal neurons of aged rats induced by D-galactose(D-gal).Methods D-gal was used to induce the model of aging rat,PQQ was administered into rat lateral intracerebroventricle.After 50 days the metamorphosis of hippocampal neurons was observed by H-E and Nissl's staining.The apoptosis rate of hippocampus was tested by flow cytometry.The contents of free radical and C-FOS protern were measured.Results Compared with the control group,the size of the neurosoma was slightly changed,the optical density of Nissl's was decreased,the content of free radical and the apoptosis rate increased markedly in D-gal group.After PQQ injection with D-gal,the size of neurosoma and the optical density of Nissl's were markedly increased,the content of free radical and the apoptosis rate of hippocampus did not change.PQQ improved the expression of C-FOS protern.Conclusion PQQ can slow down the aging progress of hippocamal neurons induced by D-gal.
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Objective To discuss the method of implant for alveolar bone deficiency.Methods 37 cases of bone deficiency were chosen to use maxillary sinus augmentation,localized management of sinus floor,autologous jaw chips transplantation,alveolar bone distraction.Results All of the implants osseointegration except 1 implant loosed because of improper prosthesis.Conclusion All of the methods above provide can good ways for wider indication of implantation.
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OBJECTIVE:To analyze the status quo and tendency of TCM injection in our hospital. METHODS:Consumption sum,DDDs and DDDC of TCM injections in our hospital from 2006 to 2009 were analyzed statistically. RESULTS:The consumption sum of TCM injections increased year by year. The consumption sum of TCM injection was increased by 40.24% in 2007 and 32.66% in 2008 while it was decreased by 1.84% in 2009. The proportions of consumption sum of TCM injection in total consumption sum of drugs in 4 years were 2.59%,3.43%,3.98% and 3.30% respectively,showing yearly increasing trend. CONCLUSION:The application of TCM injection in our hospital shows a reasonable increase. Clinical pharmacists have rational reaction to ADR and adverse events caused by TCM injections.