ABSTRACT
Objective To investigate the effect of montelukast combined with budesonide suspension inhalation in the treatment of children with cough variant asthma (CVA),and its effect on inflammatory cytokines. Methods 96 patients with CVA were selected ,and they were randomly divided into observation group ( n=48 ) and control group ( n=48 ) according to the digital table .The control group was treated with routine western medicine only.On the basis of the control group , the observation group was treated with aerosol inhalation of budesonide suspension and montelukast sodium tablets .The children in the two groups were treated for 3 months, then the treatment effect was evaluated.Results The total effective rate in the observation group was 95.8％,which was significantly higher than 77.1％in the control group(χ2 =4.914,P<0.05).After treatment,the FVC,FEV1,FEV1/FVC and PEF in the two groups were significantly improved (t=4.98,3.09,4.33,4.11,all P<0.01).There were statistically significant differences between the two groups after treatment (t=2.03,2.15,2.33,2.91,all P<0.01). After treatment,the MDA level of the observation group was significantly lower ,SOD value was significantly higher , compared with before treatment,the differences were statistically significant(t=5.13,4.09,all P<0.01).But there were no statistically significant differences between before and after treatment in the control group (t=0.12,0.32,all P>0.05).After treatment,the levels of IL-8,IL-6 and TNF-αin the two groups were significantly lower than before treatment(t=2.09,3.13,2.97,all P<0.01).The decrease of inflammatory cytokines was more significant in the observation group(t=2.67,3.45,2.14,all P<0.01).After treatment,the levels of IgA and IgG in the observa-tion group were significantly higher than those in the control group (all P<0.05),but the IgM level in the observation group was not significantly changed (t=3.44,3.53,3.22,all P<0.05).The IgE,IgM and IgG levels in the control group were significantly lower than those before treatment (t=2.09,2.33,2.76,all P>0.05).There were no serious adverse reactions in the treatment group , and the treatment cycle was completed successfully .Conclusion Monte-lukast combined with budesonide suspension inhalation in the treatment of children with CVA can significantly improve pulmonary ventilation function , reduce cough symptoms , it is safe and effective , which is worthy of clinical reference .
ABSTRACT
Objective To discuss the application of combined probiotics pretreatment and late triple therapy with helicobacter pylori infection in children.Methods 300 children with helicobacter pylori infection were randomly divided into three groups according to the way of random table.Group A was treated with standard triple therapy, omeprazole,amoxicillin and clarithromycin treatment,and 10 d was 1 treatment course.B group was given probiotic pretreatment,prior to the triple therapy using compound lactobacillus acidophilus piece 1 piece /time,cold water to take after meals,taking 2 weeks,follow -up treatment with triple therapy for 10d.In group C,triple therapy before using compound lactobacillus acidophilus piece 1 piece /time,cold water to take after meals,taking 2 weeks,follow -up treatment with triple therapy for 10d.To take one week after the completion of compound lactobacillus acidophilus piece 1 piece /time,cold water after meals.The clinical therapeutic effects were recorded.Results The helicobacter pylori clearance rate of group A was 55.00%,that of group B was 86.00%,that in group C was 89.00%,the helico-bacter pylori clearance rate of group B and group C was significantly higher than that in group A,the difference was statistically significant (χ2 =23.103 7,28.670 6,all P 0.05 ).In A group,nausea and vomiting occurred in 5 cases,2 cases of diarrhea,abdominal distension abdominal pain in 4 cases,skin rash in 5 cases.In group B,nausea and vomiting occurred in 2 cases,0 cases of diarrhea,abdominal distension abdominal pain in 1 case,skin rash in 1 case.In group C,nausea and vomiting occurred in 1 case,0 cases of diarrhea,abdominal distension abdominal pain 0 cases,skin rashes in 1 case.The incidence rate of adverse reactions in group B and group C was lower than that in group A,the difference was statistically significant (χ2 =11.965 8,8.000 0,all P 0.05). Conclusion Joint probiotics pretreatment and late triple therapy application in helicobacter pylori in children can promote helicobacter pylori clearance,reduce the triple therapy drug adverse reactions,it is worthy of popularization and application in clinic.