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Objective To evaluate the clinical effect and prognostic factors of patients with liver metastases treated with three dimensional conformal radiation therapy (3-DCRT) with boost radiotherapy.Methods From Jan 2010 to Jan 2016,120 patients of liver metastases treated in the Third Rradiotherapy Department of the Third Affiliated Hospital of Harbin Medical University (all patients were treated for the first time and were not suitable for surgical treatment) were restrospectively analyzed.Results 1,2,3-year survival rates were 74.7％,20.2,13.5％,median survival was 19 months.For univariate analysis,those with less number of extrahepatic organ metastasis,fewer liver metastases,smaller size of liver metastases,higher radiation dose,no chemotherapy before radiation and Karnofsky score ≥80 points were with higher 1-,2-and 3-year survival rate and longer median survival time (P ＜ 0.05).Multivariate analysis showed that the number of involved extrahepatic organs,the maximum diameter of liver metastases,numbers of metastases and radiation dose are independent factors to affect the survival of patients with liver metastases (P ＜ 0.05).Conclusions Patients with liver metastases treated with 3D-CRT and boost radiotherapy have satisfactory local control and 1,2,3-year survival rate as well as lower incidence of toxicity damage to the liver.
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Lung metastasis is one of the most common metastases.Metastasectomy is only indicated for selected patients,and most patients are unsuited to surgery.The main treatment is systemic chemotherapy,however,the long-term survival is limited.With the development of precision radiotherapies such as threedimensional conformal radiation therapy (3D-CRT) and stereotactic body radiotherapy (SBRT),it is proved that radiotherapy is favorable for the patients with lung metastasis,especially for limited lung metastasis.SBRT can be obtained better survival,but still need large prospective studies.
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0.05); The result of FCM indicates that the cells transfected with p16 changed in cell cycle distribution ; proportion of G 2 M phase was increased, while that of S phase was decreased.Conclusions:Introduction of p16 gene into low expression human lung adenocarcinoma cell line Anip973 alters the radiation effect in a way which perhaps was correlated with the inhibition of sublethal damage repair and the cell cycle distribution change, but not in the high expression cell line AGZY83a.
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90%) was a forepart change of gemcitabine-induced lung injury in the first month in G group, but the exudation, proliferation and fibrosis dominated in the 1,3 and 6 months in R+CG group. Hydroxyproline content of lung-irridiated tissue was increased from the 5th month and lasted to months 6,7 and 8, and its content in the R+CG group was higher than that in the other groups(P