ABSTRACT
BACKGROUND:Vascularization is essential for wound healing and functional recovery during soft tissue repair.Adipose tissue is believed to be the body's largest source of stem cells,and a number of different fat complexes have been developed for research and treatment.Its ability to promote angiogenesis and soft tissue repair has been extensively studied. OBJECTIVE:To review the progress of vascularization in soft tissue repair,and to summarize the preparation methods of adipose tissue and its derivative and their applications in vascularization and soft tissue repair.It is proven that adipose tissue and its derivative have excellent research value and clinical application prospects in vascular and soft tissue engineering. METHODS:PubMed,Web of Science and CNKI databases were used to search the related articles published from January 2010 to February 2023.The search terms were"soft tissue repair,wound healing,vascularization,angiogenesis,adipose tissue,stromal vascular fraction,adipose tissue-derived microvascular fragment,nanofat,adipose extracellular matrix/stromal vascular fraction gel"in Chinese and English.A small number of old classic literature was also included.An initial screening was performed by reading the titles and abstracts to exclude literature that was not relevant to the topic of the article,and 69 papers were finally included for the analysis of the result. RESULTS AND CONCLUSION:(1)Wound healing is an important physiological process,which mainly occurs when tissue is damaged,such as injury,surgery,burn,tumor,infection and vascular disease caused by tissue damage and defects.(2)Adequate vascularization of the wound site is essential for tissue repair,reconstruction of local homeostasis and functional recovery.(3)Adipose tissue is believed to be the body's largest pool of stem cells and a number of different fat components have been used for research and treatment.(4)Due to its inherent composition and preparation advantages,adipose tissue will continue to play an important role in tissue engineering research and therapy.
ABSTRACT
Objective@#To explore the treatment effects of edaravone combined with antiviral drugs on 30 adult cases with viral encephalitis.@*Methods@#Sixty adult patients with viral encephalitis in our hospital were selected for the study and were divided into control group and observation group according to the admission number, with 30 cases in each group. Control group was treated with conventional antiviral drugs, and observation group was given antiviral drugs combined with edaravone. Another 30 healthy people admitted to the hospital in the same period for physical examination were included in healthy group. The clinical efficacy and time to normalization of clinical manifestations (fever, headache, vomiting, EEG abnormalities) were recorded in observation group and control group, and the oxidative stress indicators [catalase (CAT), lipids peroxide (LPO)] and nerve injury indexes [neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP)] were compared between observation group, control group and healthy group before treatment and after 2 weeks of treatment. The neurological deficit [National Institutes of Health Stroke Scale (NIHSS)] was observed in observation group and control group.@*Results@#The clinical efficacy in observation group was significantly better than that in control group (P<0.05), and the normal recovery times of fever, headache, vomiting and abnormal EEG were lower than those in control group (P<0.05). After 2 weeks of treatment, the partial oxidative stress index (serum CAT) in observation group and control group was higher than that before treatment (P<0.05) while partial oxidative stress index (serum LPO), nerve injury indexes (serum NSE, GFAP) and neurological defect (NIHSS score) were lower than those before treatment (P<0.05), and the changes in observation group were greater than those in control group (P<0.05). The serum CAT levels in the two groups before and after treatment were lower than those in healthy group (P<0.05), and the levels of LPO, NSE and GFAP were higher than those in healthy group (P<0.05).@*Conclusions@#Edaravone combined with antiviral drugs has significant treatment effects in the treatment of adult viral encephalitis. It can not only reduce the body’ s oxidative stress response, but also reduce nerve injury and improve neurological deficit, and it has a certain application value.