ABSTRACT
Perihematomal edema is common after hypertensive intracerebral hemorrhage. It is one of the important causes influencing functional recovery. This article reviews the mechanisms of perihematomal brain edema formation after hypertensive intracerebral hemorrhage, particularly, the potential mechanisms of hypertension in the processes of brain edema formation, as well as therapeutic targets of brain edema.
ABSTRACT
Objective To investigate the effect of blood pressure management on perihematomai edema in patients with acute hypertensive intracerebral hemorrhage. Methods The retrospective research method was used to conduct logistic regression analysis for the factors of age, number of days, antihypertensive drugs, dehydrating agents, and blood pressure in inpatients with hypertensive intracerebral hemorrhage from June 2005 to December 2007. Results Multivariate analysis found that both amlodipine (OR = 0. 208, 95% CI 0. 063-0. 684) and angiotensin-converting enzyme inhibitor (ACEI) (OR = 0. 280, 95% CI 0. 085-0. 920) were the protective factors for perihematomal edema; both the course of 10 to 20 days (OR =7.413, 95% CI 1. 362-40. 360) and poorly controlled diastolic blood pressure (OR = 6. 449, 95% CI 1. 011-41. 145) were the risk factors for perihematomal edema. Conclusions Amlodipine and ACEI may lower the risk of perihematomal edema in intracerebral hemorrhage, while the poorly controlled diastolic blood pressure and the course of 10 to 20 days are the risk factors for perihematomal edema.