ABSTRACT
The incidence and mortality of colorectal cancer are increasing yearly in China. Early diagnosis of colorectal cancer and advanced adenoma is an effective means to reduce the risk of cancer-related morbidity and mortality. Many studies have explored the value of stool, blood, genetic, and visualization-based diagnostic modalities and early screening strategies for the detection of colorectal cancer. There are differences in diagnostic performance, screening participation rates, and applicability among these different diagnostic methods. The quality of colonoscopy and participation rate in population for screening are key factors affecting the early diagnostic rate. The development of appropriate early screening and diagnostic strategies based on regional differences in economic, social, and health resources can lead to a better cost-effectiveness.