ABSTRACT
PURPOSE: This study aimed to use a web-based survey to investigate the correlation between job satisfaction and marital quality and to identify the association of demographics with job satisfaction and marital quality. METHODS: Married nurses (N = 2,296) completed the questionnaires. Correlations and linear regression analyses were carried out. RESULTS: Both marital quality and job satisfaction were relatively low. Additionally, marital quality was positively correlated with job satisfaction. Age, marital status (in years) and average daily hours spent with spouse had positive impact on job satisfaction. Multiple linear regression analyses showed that age, monthly income, average daily hours spent with spouse and marital quality were positively associated with job satisfaction. CONCLUSION: Because of the shifts nurses working, there is little time for nurses to spend with their spouses and family. It is recommended that hospital leaders could provide more flexibility with nurses' shift choices so nurses can arrange their work-life balance better. Other considerations like reducing workload and reducing working hours should be promoted as options. Nurse managers could offer counseling services including strategies to cope with the balance between work and life. This effort could improve job satisfaction and reduce the rate of turnover of nurses.
Subject(s)
Humans , Asian People , China , Counseling , Demography , Job Satisfaction , Linear Models , Marital Status , Nurse Administrators , Pliability , SpousesABSTRACT
Oleanolic acid (OA) is a pentacyclic triterpenoid compound extracted from olea europaeal, a traditional Chinese medicine herb. OA has been used in the clinic as a hepatoprotective medicine in China since 1970s. In our previous study, we observed that OA could ameliorate hyperlipidemia in animal models. In the present study, we conducted a small-scale clinical trial to evaluate the hypolipidemia effect of OA in hyperlipidemic patients. Hyperlipidemic patients were administrated with OA for four weeks (4 tablets once, three times a day). The blood samples of the patients were collected before and after OA treatment. The biological parameters were measured. Furthermore, three patients' blood samples were studied with DNA microarray. After OA administration, the TC, TG, and HDLC levels in serum decreased significantly. DNA microarray analysis results showed that the expressions of 21 mRNAs were significantly changed after OA treatment. Bioinformatics analysis showed 17 mRNAs were up-regulated and 4 mRNAs were down-regulated significantly after OA treatment. Five mRNAs (CACNA1B, FCN, STEAP3, AMPH, and NR6A1) were selected to validate the expression levels by qRT-PCR. Therefore, OA administration differentially regulated the expression of genes involved in lipid metabolism. The data showed a clinical evidence that OA could improve hyperlipidemia and also unveiled a new insight into the molecular mechanisms underlying the pharmacological effect of OA on hyperlipidemia.
Subject(s)
Female , Humans , Male , Middle Aged , China , Computational Biology , Drugs, Chinese Herbal , Pharmacology , Therapeutic Uses , Gene Expression Profiling , Gene Expression Regulation , Hyperlipidemias , Blood , Drug Therapy , Genetics , Metabolism , Lipid Metabolism , Oleanolic Acid , Pharmacology , Therapeutic Uses , RNA, Messenger , Genetics , Treatment OutcomeABSTRACT
Oleanolic acid (OA) is a pentacyclic triterpenoid compound extracted from olea europaeal, a traditional Chinese medicine herb. OA has been used in the clinic as a hepatoprotective medicine in China since 1970s. In our previous study, we observed that OA could ameliorate hyperlipidemia in animal models. In the present study, we conducted a small-scale clinical trial to evaluate the hypolipidemia effect of OA in hyperlipidemic patients. Hyperlipidemic patients were administrated with OA for four weeks (4 tablets once, three times a day). The blood samples of the patients were collected before and after OA treatment. The biological parameters were measured. Furthermore, three patients' blood samples were studied with DNA microarray. After OA administration, the TC, TG, and HDLC levels in serum decreased significantly. DNA microarray analysis results showed that the expressions of 21 mRNAs were significantly changed after OA treatment. Bioinformatics analysis showed 17 mRNAs were up-regulated and 4 mRNAs were down-regulated significantly after OA treatment. Five mRNAs (CACNA1B, FCN, STEAP3, AMPH, and NR6A1) were selected to validate the expression levels by qRT-PCR. Therefore, OA administration differentially regulated the expression of genes involved in lipid metabolism. The data showed a clinical evidence that OA could improve hyperlipidemia and also unveiled a new insight into the molecular mechanisms underlying the pharmacological effect of OA on hyperlipidemia.
Subject(s)
Female , Humans , Male , Middle Aged , China , Computational Biology , Drugs, Chinese Herbal , Pharmacology , Therapeutic Uses , Gene Expression Profiling , Gene Expression Regulation , Hyperlipidemias , Blood , Drug Therapy , Genetics , Metabolism , Lipid Metabolism , Oleanolic Acid , Pharmacology , Therapeutic Uses , RNA, Messenger , Genetics , Treatment OutcomeABSTRACT
<p><b>OBJECTIVE</b>To study the anti-fatigue mechanism of salidroside from Rhodiola SachalinensisA.Bor (SRS)in anti-oxidation and energy metabolic systems in mice , some related indexes of free radical and energy metabolism after exercise were measured.</p><p><b>METHODS</b>Forty male mice were divided into four groups (n = 10): SRS sport group(SS), SRS quiet group(SQ),sport control group(SC), quiet control group (QC). The mice of SS and SQ groups received SRS solution of 150 ml/kg body weight per day for two weeks, while the mice of SC and QC groups received the same volume of distilled water. 30 min after the last treatment, the mice of SS and SC groups were forced to swim for 120 min without loads. then the biochemical parameters related to fatigue were determined.</p><p><b>RESULT</b>SRS could increase liver superoxide dismutase (SOD) , glutathione peroxidase (GSH-Px) activity of antioxidant enzymes and reduce the malondialdehyde (MDA) content, which might increase the body activity of antioxidant enzymes to play the role of anti-oxidation; SRS had some effect of stabilizing blood sugar, increasing liver glycogen and muscle glycogen reserves, preventing blood sugar, liver glycogen and muscle glycogen levels from reducing in long time exercise on mice; SRS could increase plasma total cholesterol (TC), triglyceride (TG) and free fatty acid (FFA) levels in exercise mice, and it had some effect on metabolism of fat under different conditions, and promoted the use of the role of fat.</p><p><b>CONCLUSION</b>Influence of SRS on some related indexes of free radical and energy metabolism is one of the mechanisms of anti-exercise-induced fatigue of SRS.</p>
Subject(s)
Animals , Male , Mice , Energy Metabolism , Free Radicals , Metabolism , Glucosides , Pharmacology , Malondialdehyde , Metabolism , Mice, Inbred Strains , Phenols , Pharmacology , Physical Conditioning, Animal , RhodiolaABSTRACT
Facing the inadequate status quo of postgraduate courses teaching methods,evaluation system,the author tries to reform the teaching methods in the required course introduction to research methods of pharmacology.Based on the application of the virtual lab in drug discovery,the author adopted the ways of explaining and publicizing the subject beforhand to let the students retrieve and organize materials,and make presentations in class about the literature they have retrieved within the limited time so that the teacher could give comprehensive evaluation according to their content and performances.Through this reform I realized that the organizating the teaching materials from multi-angles can raise the information quantity,which will help students take initiatives to gain as much information as possible so as to improve their thinking ability,lengthen their attention span,arouse their interest and enhance their study efficiency.So with network technology proping up,it is advisable to adopt such study style of individuation and autonomy.