ABSTRACT
Glutamate serves as a major excitatory neurotransmitter in the mammalian central nervous system and is stored in synaptic deft by an uptake system that is dependent on the high-affinity glutamate transporters (ETTAs),which locate in the plasma membrane of glial cells and neurons.ETTAs can rapidly terminate the action of glutamate and maintain its normal physiological functions.If the content or function of glutamate transporters is abnormal,it can result in many physiological dysfunctions.Studies have demonstrated that high-affinity glutamate transporters play an important role in the development of chronic pain,which might be a new therapeutic target for the pain.
ABSTRACT
Objective: To determine anti oxygen free radical (anti OFR) function in each herb of Kangqianling Granules and its compound prescription. Method:The anti OFR function in herbs was tested in vitro by means of chemical luminescence .Results: The anti OFR functions of Radix et Rhizoma Rhei and Radix Salviae Miltiorrhizae are the best, other herbs also have a bit of effects.Conclusion: Kangqianling Granules retarding CRF's course can be related to it’s anti OFR function.