ABSTRACT
Objective:To establish a predictive model and investigate its value in evaluating short-term prognosis of patients with hepatitis B virus related acute-on-chronic liver failure (HBV-ACLF).Methods:Patients with HBV-ACLF admitted to Tianjin Second People's Hospital and Beijing Youan Hospital, Capital Medical University from May 2015 to October 2018 were enrolled. The data of gender, age, laboratory markers at admission, model for end-stage liver disease (MELD) score and clinical complications were collected for analysis. According to the prognosis on 12-week, patients were divided into survival group and death group. Univariate analysis and binary Logistic regression analysis were used to test the risk factors for short-term prognosis of the patients with HBV-ACLF, and a prediction model was established. The accuracy of each index and the established model were verified by the receiver operating characteristic (ROC) curve.Results:A total of 148 patients with HBV-ACLF were enrolled in the study, 91 cases survived while 57 cases died during the 12-week period. The age, total bilirubin (TBIL), neutrophil percentage (NEUT%), hepatitis B surface antigen (HBsAg), MELD score of death group were higher than those of survival group [age (years old): 50.00 (44.50, 55.00) vs. 43.00 (34.00, 53.00), TBIL (μmol/L): 310.30 (240.70, 405.70) vs. 266.40 (184.20, 360.20), NEUT%: (74.52±13.05)% vs. (66.64±12.35)%, lg HBsAg (kU/L): 3.72 (3.29, 3.92) vs. 2.97 (2.49, 3.78), MELD score: 24.27 (19.71, 27.40) vs. 21.88 (18.83, 24.38), all P < 0.05], while albumin (ALB), total cholesterol (CHO), prothrombin activity (PTA) and alpha-fetoprotein (AFP) were lower than those of survival group [ALB (g/L): 29.80 (27.05, 31.05) vs. 30.80 (28.00, 33.90), CHO (mmol/L): 1.98 (1.50, 2.38) vs. 2.49 (2.05, 3.01), PTA: (30.37±7.09)% vs. (32.94±6.03)%, AFP (μg/L): 21.54 (9.28, 51.54) vs. 66.16 (24.50, 152.80), all P < 0.05]. Logistic regression analysis showed that NEUT%, HBsAg and AFP were independent risk factors for short-term prognosis of patients with HBV-ACLF [odds ratio ( OR) was 77.843, 1.439, 0.995, respectively, all P < 0.05]. According to the results of regression analysis, the NHA-ACLF model (NEUT%+HBsAg+AFP) was established. The formula was logit (NHA-ACLF) = -5.441+5.688×NEUT%+0.430×lg HBsAg-0.005×AFP. The area under the ROC curve (AUC) of the NHA-ACLF model for pred HBV-ACLF patients was 0.790, which was better than NEUT% (AUC = 0.696), lg HBsAg (AUC = 0.670), AFP (AUC = 0.703) and MELD score (AUC = 0.640). When the cut-off value of NHA-ACLF model score was 0.459, the sensitivity was 73.7%, and the specificity was 79.1%. Conclusions:NEUT%, HBsAg and AFP are independent predictive indicator for short-term prognosis in patients with HBV-ACLF. Compared with MELD score, the risk assessment model NHA-ACLF has a greater value in predicting the short-term prognosis of patients with HBV-ACLF.
ABSTRACT
Liver failure belongs to the category of jaundice and yellow plague in the traditional Chinese medicine. It has something in common with the etiology and pathogenesis of jaundice. In Synopsis of Prescriptions of the Golden Chamber, the theories, methods, prescriptions and drugs for jaundice are systemically explained, and the related therapeutic principles and methods are proposed, that have profound influence on the treatment of jaundice for later generations. From the point of view upon the treatment of jaundice in Synopsis of Prescriptions of the Golden Chamber, the treatment of liver failure is discussed in this article. The author thinks that the "dampness, heat and blood stasis" are the pathological bases of jaundice, but the heat phenomenon is more obvious in the course of the disease, and at later stage"deficiency" is significant; the basic principle of the treatment of liver failure should first comply with clearing away heat and promoting diuresis, using the drugs heavily for heat-clearing and detoxifying to block the disease as the main line especially at the beginning stage, drugs for activating blood circulation and removing blood stasis are applied from the beginning to the end of the treatment, and in the mean time, regulation of spleen and stomach and tonification of spleen and kidney should be paid attention to especially at the later stage. The application and skill of making Yinchenhao decoction for treatment of jaundice is also important.
ABSTRACT
Liver failure belongs to the category of jaundice and yellow plague in the traditional Chinese medicine. It has something in common with the etiology and pathogenesis of jaundice. In Synopsis of Prescriptions of the Golden Chamber, the theories, methods, prescriptions and drugs for jaundice are systemically explained, and the related therapeutic principles and methods are proposed, that have profound influence on the treatment of jaundice for later generations. From the point of view upon the treatment of jaundice in Synopsis of Prescriptions of the Golden Chamber, the treatment of liver failure is discussed in this article. The author thinks that the "dampness, heat and blood stasis" are the pathological bases of jaundice, but the heat phenomenon is more obvious in the course of the disease, and at later stage"deficiency" is significant; the basic principle of the treatment of liver failure should first comply with clearing away heat and promoting diuresis, using the drugs heavily for heat-clearing and detoxifying to block the disease as the main line especially at the beginning stage, drugs for activating blood circulation and removing blood stasis are applied from the beginning to the end of the treatment, and in the mean time, regulation of spleen and stomach and tonification of spleen and kidney should be paid attention to especially at the later stage. The application and skill of making Yinchenhao decoction for treatment of jaundice is also important.