ABSTRACT
Objective To evaluate the efficacy and safety of trimebutine combined with mosapride on functional dyspepsia. Methods Patients with functional dyspepsia were randomly divided into three clinical groups. Group A (n=116) received 0.2 g trimebutine after meal,group the drug combination B (n=116) received 5 mg mosapride before meal,and the drug combination group (n=115) received 0. 2 g trimebutine after meal plus 5 mg mosapride before meal. All medications were taken orally three times daily for 4 weeks. Improvement in clinical symptoms and adverse reactions in each group were evaluated at the end of study. Results A total of 339 patients among 347 enrollees completed the treatment and follow-up. The clinical efficacy on postprandial fullness, early satiation, epigastric pain, epigastric burning, upper abdominal bloating and nausea were 88. 4%,76. 9%,72. 9%,61. 8%,86. 7% and 81. 7%,respectively in the drug combination group after 4-week treatment,which were superior to those in group A or B (P<0. 05) except for epigastric burning. The total effective rate of the drug combination group was 78. 8%,significantly higher than the other two groups (P<0. 05). The total incidence of side effects in the drug combination group was 1. 8%,similar to that of group A and B (1. 8% and 0. 9%,respectively, P =0. 776). Conclusion Trimebutine combined with mosapride is safe and effective for improving symptoms in functional dyspepsia.
ABSTRACT
Objective To investigate the clinical effect of three dimensional conformal radiation therapy combined with EP regimen for limited-stage of small cell lung cancer in elderly.Methods A total of 83 elder patients with limited-stage of small cell lung cancer were divided into treatment group and control group by random digits table method.In treatment group,42 patients received three dimensional conformal radiation therapy with synchronized EP regimen chemotherapy.In control group,41 patients received 2 cycles of EP regimen chemotherapy in advance,then received three dimensional conformal radiation therapy.Results The complete remission rate and objective response rate of treatment group and control group had significant differences [45.2％ (19/42) vs.17.1％ (7/41),81.0％ (34/42) vs.51.2％ (21/41)] (P =0.006,0.004).Follow-up for 2 years,there were 2 patients lost in treatment group,there was 1 patient lost in control group.The 1,2 years survival rate of treatment group and control group had significant difference [87.5％(35/40) vs.60.0％(24/40),65.0％(26/40) vs.32.5％(13/40)](P =0.005,0.004).The incidence of leukopenia,anemia,radiation pneumonitis and radiation esophagitis in treatment group were higher than those in control group,but there were no significant differences (P＞ 0.05).The 2-year local recurrence rate and distant metastasis rate of treatment group and control group had significant differences [17.5％(7/40) vs.42.5％ (17/40),32.5％ (13/40) vs.62.5％ (25/40)] (P =0.015,0.007).Conclusions Three dimensional conformal radiation therapy combined with EP regimen for limited-stage of small cell lung cancer in elderly can improve the short-term efficacy,long-term survival and reduce the rate of local recurrence and distant metastasis.It is safe and effective in the treatment of limited-stage of small cell lung cancer in elderly.