ABSTRACT
Objective To investigate the expression of TFPT in non-small cell lung cancer (NSCLC), evaluate its clinical significance and study its influence on NSCLC. Methods Total of 50 specimens of carcinoma tissues and para-carcinoma tissue after surgery were collected.Then qRT-PCR was performed for TFPT expression. The correlations between the expression of TFPT and pathological characteristics were analyzed.pcDNA3.1-TFPT was transfected to up-regulate TFPT expression in A549 cells,and the transfection efficiency was evaluated by qRT-PCR.CCK8 assay was performed to evaluate the effects of ectopic TFPT on proliferation of A549 cells.The expression of TCF3 protein was determined by Western blot.Results The expression level of TFPT was up-regulated in tumor tissue compared with that in the para-carcinoma tissue. The expression of TFPT was associated with patients'gender, tumor size, differentiation degree, lymphatic metastasis and the distal metastasis (P < 0.01). Meanwhile, overexpression of TFPT increased the expression of TCF3 and the proliferation of A549 cells. Conclusions The expression of TFPT is obviously increased in NSCLC patients of female,larger tumor size, higher clinical stage or advanced histological grade. TFPT may promote cell proliferation by affecting the expression of TCF3 proteins.
ABSTRACT
Objective To explore the efficacy of standardized diabetes self-management education program. Methods A total of 200 cases of diabetes patients were divided into experimental group and control group with 100 cases each by random digits table method. For experimental group, the patients received standardized diabetes self-management education, for control group, traditional management and occasional telephone follow-up, for 6 months. Blood glucose metabolism, lipid, diabetes self-management ability were evaluated. Results The score in diet control, exercise therapy, medication, self-blood glucose monitoring, complication prevention and self-management ability of experimental group were (20.56 ± 1.23), (15.57 ± 1.62), (13.95 ± 1. 85), (14.62 ± 6.81), (31.65 ± 1.95) , (96.52 ± 1.28) points, and the score of control group were (19.74±1.36), (13.67±3.82), (12.66±1.03), (12.26±2.29), (29.56±1.76), (90.36± 1.94) points. Compliance of two group was improved, and experimental group much better ( t=3.53-5.82, all P<0.05). The fasting blood glucose, postprandial 2h blood glucose, glycosylated hemoglobin, triacylglycerol and total cholesterol of experimental group were (5.52±1.32) mmol/L, (7.69±3.62) mmol/L, (6.22±4.21)%, (1.42±1.28) mmol/Land (4.36±1.27) mmol/L, and those of control group were (6.56±1.23) mmol/L, (8.78±5.42) mmol/L, (7.12±4.29)%, (1.78±1.49) mmol/L and (4.71±2.14) mmol/L. Metabolism of two group was improved, and experimental group much better (t=4.93-6.78, all P<0.05). Conclusions Standardized diabetes self-management education is better than traditional management. It is worthy of clinical application.
ABSTRACT
Objective To explore the efficacy of standardized diabetes self-management education program. Methods A total of 200 cases of diabetes patients were divided into experimental group and control group with 100 cases each by random digits table method. For experimental group, the patients received standardized diabetes self-management education, for control group, traditional management and occasional telephone follow-up, for 6 months. Blood glucose metabolism, lipid, diabetes self-management ability were evaluated. Results The score in diet control, exercise therapy, medication, self-blood glucose monitoring, complication prevention and self-management ability of experimental group were (20.56 ± 1.23), (15.57 ± 1.62), (13.95 ± 1. 85), (14.62 ± 6.81), (31.65 ± 1.95) , (96.52 ± 1.28) points, and the score of control group were (19.74±1.36), (13.67±3.82), (12.66±1.03), (12.26±2.29), (29.56±1.76), (90.36± 1.94) points. Compliance of two group was improved, and experimental group much better ( t=3.53-5.82, all P<0.05). The fasting blood glucose, postprandial 2h blood glucose, glycosylated hemoglobin, triacylglycerol and total cholesterol of experimental group were (5.52±1.32) mmol/L, (7.69±3.62) mmol/L, (6.22±4.21)%, (1.42±1.28) mmol/Land (4.36±1.27) mmol/L, and those of control group were (6.56±1.23) mmol/L, (8.78±5.42) mmol/L, (7.12±4.29)%, (1.78±1.49) mmol/L and (4.71±2.14) mmol/L. Metabolism of two group was improved, and experimental group much better (t=4.93-6.78, all P<0.05). Conclusions Standardized diabetes self-management education is better than traditional management. It is worthy of clinical application.