ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of direct moxibustion at Sihua points on immune function and life quality of chemotherapy patients with non-small cell lung cancer.</p><p><b>METHODS</b>Eighty cases were randomly divided into a chemotherapy and moxibustion group (group A) and a chemotherapy group (group B), 40 cases in each one. Navelbine and cisplatin were applied in both groups. In addition, direct moxibustion at Sihua points which included Geshu (BL 17) and Danshu (BL 19) was used in the group A. Three moxa-cones were given on each acupoint, once a day, ten days treatment made one session and totally one session was required. The change of colony stimulating factor (CSF), tumor necrosis factor (TNF), interleukin-2 (IL- 2) and Karnofsky scale was compared between the two groups before and after treatment.</p><p><b>RESULTS</b>After the treatment, the levels of serum CSF, IL-2 in the group A were higher than those in the group B (both P < 0.01), while the level of TNF in the group A was lower than that in the group B (P<0. 01). Although Karnofsky score was decreased in the two groups (both P < 0.01), the score in the group A was higher than that in the group B (P < 0.01).</p><p><b>CONCLUSION</b>Direct moxibustion at Sihua points could increase the levels of CSF and IL-2 and reduce TNF in the chemotherapy patients with lung cancer, which could improve immune function, clinical efficacy and life quality.</p>