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Rev. bras. neurol ; 45(2): 13-20, abr.-jun. 2009. ilus
Article in Portuguese | LILACS | ID: lil-518010

ABSTRACT

O trabalho de revisão sistemática aponta os principais aspectos patogênicos relacionados às lesões neurais e vasculares da neuropatia diabética, estudados em modelos animais. Tem como escopo comparar as diversas espécies animais utilizadas nos estudos, salientando os aspectos semelhantes encontrados nos animais e os ocorrentes na doença humana. Foram revistos os trabalhos publicados a partir de 2000, inserindo-se alguns anteriores que serviram de referência para trabalhos atuais.


The systematic review shows the main aspects related to pathological neural and vascular lesions of diabetic neuropathy, studied in animal models. It has the scope to compare the various species of animals used in studies, highlighting the similar aspects found in animals and the issues occurring in human disease. We reviewed the papers published since 2000, as well as some earlier ones that served as a reference for the present studies.


Subject(s)
Animals , Cats , Dogs , Rats , Diabetes Mellitus , Diabetes Mellitus, Experimental/chemically induced , Diabetic Neuropathies/pathology , Review Literature as Topic , Streptozocin , Models, Animal , Alloxan
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