ABSTRACT
ABSTRACT This systematic review aimed to identify the pathogens causing or associated with congenital microcephaly in Brazil in the last 20 years due to the lack of official information by the Health Authorities and, as a consequence the uncertainty on the real infectious etiology of congenital microcephaly. A review protocol was prepared according to the PRISMA recommendation, using the PubMed, SciELO and LILACS databases to search for references presenting original data on microcephaly caused by or associated with congenital infectious in Brazil, using the descriptors "MICROCEPHALY AND INFECTION". The search ended on 30/Jun/2020. All selected titles were read in full and analyzed independently by the three reviewers. After searching the databases, 2,389 articles were selected for title review. Of these, 109 were excluded due to duplicates and 2,236 according to the criteria defined in the review. Only 44 met the eligibility criteria and were therefore read in full. Data extraction was performed on 10 articles, all published after 2015. Seven studies were literature reviews or case series, only two were case-control, and one was a cross-sectional study. As the studies focused on the period of the ZIKV epidemic in Brazil, the cases of congenital microcephaly between 2015 and 2017 were attributed to maternal infection by this virus when it was not possible to prove the presence of other etiological agents. Among the TORCH agents, a predominance of syphilis was observed. The analyzed studies did not add consistent information about the infectious causes or association of microcephaly in Brazil outside the period of ZIKV epidemic, revealing the need for more studies on the subject.
ABSTRACT
Abstract Listeria is an unusual pathogen that causes neonatal infection with high morbidity and mortality. We present the case of a premature newborn whose mother had a rash during pregnancy; the newborn had severe early sepsis because of Listeria monocytogenes and histopathologically suggestive findings of the placenta. Obstetricians and neonatologists should suspect listeriosis in cases with compatible epidemiological history, clinical features, and examination findings of the placenta.
Subject(s)
Humans , Male , Female , Pregnancy , Infant, Newborn , Adult , Young Adult , Sepsis/microbiology , Infant, Newborn, Diseases/diagnosis , Listeriosis/microbiology , Listeria monocytogenes/isolation & purification , Pregnancy Complications, Infectious , Intensive Care Units, Neonatal , Sepsis/diagnosis , Infectious Disease Transmission, Vertical , Infant, Newborn, Diseases/microbiology , Listeriosis/diagnosis , Listeriosis/transmissionABSTRACT
O desenvolvimento do suporte intensivo para recém-nascidos de baixo peso ao nascimento vem introduzindo ao longo do tempo, escores de predição de mortalidade, baseados na análises da gravidade inicial destes pacientes...Uma vez que o peso de nascimento por si só não discrimina quais os fatores que determinarão o óbito entre pacientes em uma mesma faixa de peso, a aplicação dos escores se faz necessária para estabelecer a gravidade dos pacientes. Sendo assim, estes escores só devem ser utilizados para estudos populacionais e comparações entre serviços e não como instrumento para decidir condutas terapêuticas individualmente, simplesmente baseado em um escore inicial alto, o qual eleva o risco de mortalidade.