ABSTRACT
Context Oral squamous cell carcinoma (OSCC) has a multifactorial aetiology. Risk factors such as individual's lifestyle like chronic use of tobacco, spicy food, alcohol and smoking are associated with cancer. Recent studies have revealed the possibility of ABO blood group antigens role in development of cancer. Aims and objectives To detect and correlate ABO blood group type in oral potentially malignant disorders (OPMDs) and OSCC and to compare the ABO blood group type among controls, OPMDs and OSCC. Materials and methods Study included 100 subjects, 35 cases each of OPMDs and OSCC and 30 controls. ABO blood grouping was carried out by standard agglutination method (Spanclone ARKRAY Health Care Private Limited) based on the principle of haemagglutination reaction. Results We found that OPMDs and OSCC subjects to be more prevalent among cases with B blood group. There was a significant variation in age (P=0.004), sex (P=0.004) and blood group (P= 0.003) among controls, OPMDs and OSCC. Conclusion ABO blood grouping may be used as one of the diagnostic marker for OPMDs and OSCC.
ABSTRACT
Context Oral squamous cell carcinoma (OSCC) is one of the most common cancers in human population and has a multifactorial aetiology. It is often preceded by oral potentially Malignant Disorders (OPMDs). Studies have shown that OSCC and OPMDs cause significant variations in various haematological parameters. Aim and objectives To assess the role of haematological parameters like haemoglobin, erythrocyte sedimentation rate, red blood cell count, white blood cell count and differential leukocyte count in OPMDs and OSCC and also to compare these parameters among OPMDs, OSCC and controls. Materials and methods Study comprises 30 diagnosed cases each of OPMDs and OSCC and 10 normal healthy age and sex-related individuals. Blood sample was collected from the patients and was evaluated for various haematological parameters by Sahli's acid haematin method, Westergren method and Coulter Counter ZF-6. Results There was a statistically significant difference in haemoglobin, red blood cell count, erythrocyte sedimentation rate, differential leukocyte count between OSCC, OPMDs and controls. Conclusion In the present study, haematological parameters were significantly altered in OPMDs and OSCC, and these variations may be useful in the prediction of malignant transformation and prognosis.