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Background : Meliodosis is an infection by Burkholderia Pseudomallei, is now endemic in India. It can have varied clinical manifestations. We report a case of Meliodosis in a diabetic patient presented as multiple Splenic Abcesses. Case Report : A 56-year-old male patient, manual labour, diabetic with uncontrolled glycemic levels presented with prolonged Fever and abdominal pain which on evaluation revealed multiple Splenic Abscesses. Culture of aspirate from abscess grew Burkholderia Pseudomallei. He improved with appropriate antibiotic therapy and Splenectomy. Conclusion : The case is presented to highlight the importance of making early clinical and microbiological diagnosis for a better outcome
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In the recent period there is an upsurge in the incidence of fever with thrombocytopenia in the Mid Karnataka. This may be due to the several emerging and re-emerging infections which cause frequent epidemics in the region. Early diagnosis and meticulous management will prevent fatal outcome. Studies on fever with thrombocytopenia are very few in Karnataka.METHODSThis was a descriptive study conducted at J.J.M. Medical College, Davangere, over a period of one year from December 2017 to November 2018. The study includes 251 cases attending outpatient- and inpatient-departments in the Department of Medicine. All patients with a platelet count of less than 150000 was included in this study and detailed clinical and laboratory evaluation was done and assessed for the aetiology and outcome.RESULTSAmong the 251 cases, dengue fever accounted for 54.5% of cases and 26.2% were other viral fever cases where the exact causative organism was not identified. Leptospirosis, malaria were also important causes of fever with thrombocytopenia. Major incidence of haemorrhagic manifestation occurred in the age group of 20 to 30 years whose platelet count was in the range of 10000 to 40000/mm3.CONCLUSIONSIn this study, more than 50% had dengue fever and in 26.2% cases the exact aetiology could not be determined. This finding highlights the fact that there may be many unidentified infections which cause fulminant thrombocytopenia and there is a need for wider screening of infection.
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ustification: A number of guidelines are available for management of congenital heart diseases from infancy to adult life. However,these guidelines are for patients living in high income countries. Separate guidelines, applicable to Indian children, are required whenrecommending an intervention for congenital heart diseases, as often these patients present late in the course of the disease and mayhave co-existing morbidities and malnutrition. Process: Guidelines emerged following expert deliberations at the National ConsensusMeeting on Management of Congenital Heart Diseases in India, held on 10th and 11th of August 2018 at the All India Institute of MedicalSciences, New Delhi. The meeting was supported by Children’s HeartLink, a non-governmental organization based in Minnesota, USA.Objectives: To frame evidence based guidelines for (i) indications and optimal timing of intervention in common congenital heartdiseases; (ii) follow-up protocols for patients who have undergone cardiac surgery/catheter interventions for congenital heart diseases.Recommendations: Evidence based recommendations are provided for indications and timing of intervention in common congenitalheart diseases, including left-to-right shunts (atrial septal defect, ventricular septal defect, atrioventricular septal defect, patent ductusarteriosus and others), obstructive lesions (pulmonary stenosis, aortic stenosis and coarctation of aorta) and cyanotic congenital heartdiseases (tetralogy of Fallot, transposition of great arteries, univentricular hearts, total anomalous pulmonary venous connection, Ebsteinanomaly and others). In addition, protocols for follow-up of post surgical patients are also described, disease wise.
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Background: Studies have shown that BP is an independent risk factor for CVD. This relationship is independent as well as consistent and continuous. Observations involving more than 1 million individuals have shown that death from both CVD and stroke increases progressively and linearly from BP levels of as low as 115mm systolic and 75 mm diastolic upwards. The increased risks are present in all age groups ranging from 40 to 89 years old. Hence the present study was undertaken to evaluate the factors influencing hypertension among Adults.Methods: In the present study 400 patients both out-patient and in-patients attending Adichuchanagiri Institute of Medical Sciences were evaluated for factors influencing Hypertension and other cardiovascular diseases. The 400 patients were divided into 200 cases who were again divided into categories based on severity of hypertension into stage 1 and stage 2 and duration of <5 years and ≥5 years.Results: A positive correlation was found between the severity of hypertension, the patients who were found to be having stage 2 hypertension had an increase in SUA levels which was statistically significant when compared with those with stage 1 hypertension. Conclusions: With the results based on the study carried out author concluded that there is direct relation between hyperuricemia and hypertension. Also, the study showed that the SUA levels were significantly increased in patients with Stage 2 hypertension as compared with those of stage 1 hypertension, showing that the severity of hypertension also related to the SUA levels.
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Objective The main aim of the study was to explore the factors causing delay in seeking treatment among adult patients diagnosed with CAAs acute myocardial infarction (AMI) and compare the factors between timely and late treatment seeking groups. Method A total of 93 subjects were included in the study diagnosed with AMI interviewed within 48 h of hospitalization. Data were collected from onset of symptoms to arrival at hospital on demography, clinical profile, clinical factors, cognitive factors and social support factors. Subjects were categorized in two study groups i.e. timely treatment seeking group (<120 min from onset of symptoms) and delayed treatment seeking group (>120 min from onset of symptoms). Results The minimum and maximum time took by subjects to seek treatment was 10 and 5450 min, respectively. The mean pain score of subjects who sought delayed treatment (2.2619) is less than those who sought timely treatment (3.3725). The mean knowledge score (12.2754), mean symptom perception (3.6667), mean perceived seriousness (4.7647) is more in subjects who sought timely treatment than those who sought delayed treatment (5.7381), (1.3095), (1.8333) respectively. The mean family support score (57.4492), mean non-family support score (24.902), mean social support score (48.3002) is more in timely treatment group than in delayed treatment seeking group (42.6829), (4.7619), (29.2138) respectively. Conclusion Decreased pain, knowledge about AMI, symptom perception, perceived seriousness respectively and inadequate family & non-family support i.e. social support were the factors related to treatment seeking delay among adults diagnosed with AMI.
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The leaves of Calotropis gigantea have been investigated in a systematic way covering its pharmacological aspects in an attempt to rationalize its use as drug in the indigenous system of medicine. The methanolic extract of the leaves was obtained by Soxhlet extractor. It was screened for CNS activity and found to possess sedative-hypnotic and anti-convulsant properties. These activities, when compared to standard drugs Pentobarbitone and Diazepam, were found to be highly significant [p<0.01] for sedative-hypnotic and significant [p<0.02] for anti-convulsant activities respectively
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Animals, Laboratory , Hypnotics and Sedatives , Anticonvulsants , Methanol , Plant Extracts , Plant Leaves , MiceABSTRACT
BACKGROUND: This study sought to evaluate the long-term recurrence rate of atrioventricular nodal reentrant tachycardia (AVNRT) after radiofrequency catheter ablation. The clinical and electrophysiological features of patients with AVNRT and their immediate outcomes after undergoing slow pathway ablation/modification were also studied. METHODS AND RESULTS: The study included 264 consecutive patients with AVNRT (mean age 46 -/+ 15 years, 143 women, 121 men) who underwent slow pathway ablation/modification using a combined electrophysiological and anatomical approach. The primary endpoint of ablation procedure was non- inducibility of the arrhythmia. The primary endpoint of the study was the recurrence of AVNRT on follow-up. Acute success was achieved in 262 (99.6%) patients. Complication rate of the ablation procedure was 2.6% and the average fluoroscopy time was 18.3 -/+ 11 minutes. The patients were followed up for a mean duration of 20 -/+ 9 months during which there was only one case of recurrence. CONCLUSION: Radiofrequency ablation or modification of slow pathway is highly effective in the treatment of AVNRT. The technique has a high initial success rate and a low complication rate. The recurrence rates are extremely low (0.3%) on long-term follow-up.
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Adolescent , Adult , Aged , Aged, 80 and over , Catheter Ablation , Child , Child, Preschool , Electrophysiologic Techniques, Cardiac , Female , Heart Conduction System/surgery , Humans , Male , Middle Aged , Retrospective Studies , Tachycardia, Atrioventricular Nodal Reentry/surgery , Treatment Outcome , Young AdultABSTRACT
The effect of urea, guanidine hydrochloride and sodium dodecyl sulphate on glycinin, the high molecular weight protein fraction from soybean has been investigated by analytical ultracentrifugation. Urea and guanidine hydrochloride dissociate the protein to a '2S' protein through the intermediary 7S and 4S proteins. However, in sodium dodecyl sulphate the protein directly dissociates to a 2S protein. Analysis of the data by calculation of per cent fraction and S20,w value indicates that dissociation and denaturation of glycinin occur simultaneously in the presence of the above reagents but to different extents.