Determination of association of macroprolactinemia with macroprolactinoma using poly ethylene glycol precipitation test

Prolactin in human serum exists in 3 different molecular forms, i. e, monomeric, big and at times big big [Macroprolactin]. Macroprolactin is a complex of prolactin and IgG and may account for a significant proportion of idiopathic hyperprolactinemia. Its biological activity is considered low or absent, usually idiopathic and poorly symptomatic. Since its association with a prolactin producing macroadenoma is poorly documented, we performed this study on the patients with Macroprolactinoma for the presence of macroprolactinaemia through its identification with Poly Ethylene Glycol. The study aims is to comparing the clinical [galactorrhea and oligomenorrhea] findings in patients with macroprolactinaemia and those without it. In this study 10 patients with Macroprolactinoma [macroadenoma in MRI of hypophysis, prolactin level more than l00gIL and clinical and radiological response of tumor to dopamionergic agents after treatment] were evaluated for the presence of Macroprolactinemia, using Poly Ethylene Glycol precipitation test. Doing so, one patient infected by Macroprolactinemia was detected. At the time of reception, the clinical findings in all 10 patients were classic and similar and in the follow ups, both clinical and radiological changes were the same. Our Results suggest that Macroprolactinoma may be associated with Macroprolactinemia

Dermatoglyphic assessment in down and klinefelter syndromes

Dermatoglyphics are the dermal ridge configurations on the digits, palms and soles. Dermatoglyphic polymorphism results from the co-operation of genetic and environmental factors. The Dermatoglyphic analysis is a valuable completion of initial diagnosis of some syndromes genetically determined. Our objective was to assess dermatoglyphics study results against standard chromosomal analysis in Down and Klinefelter syndromes. In this study we applied clear plastic tape and graphite powder for finger and palm prints of 90 persons. Cy-togenetic study was also performed for patients with Down [n=29] and Klinefelter [n=22] syndromes and 39 normal individuals who served as the control group. Dermatoglyphic investigations indicated that in Down syndrome, simian line, ulnar loops, whorl, t", t" and f were significant, whereas arch and interdigital III pattern were more indicative for Klinefelter syndrome. Dermatoplyphic can be used both as an initial diagnostic step and for screening purposes

role of radionuclide scanning, songraphy and fine needle aspiration cytology in palpable throid nodule diagnosis

One hundred consecutive patients with palpable thyroid nodules were enrolled in this study at Mashhad University of Medical Sciences. There were 19 males and 81 females. Age range was between 7-66 years. Most of the lesions were located in the right lobe of thyroid. 93 thyroids had a single nodule on physical examination. 99 patients had sonography. 74 of them had single and 18 had multiple nodules and one showed no nodule. In 80 cases thyroid scan was performed. In 6 patients despite a palpable thyroid nodule, scan was considered normal. 69 patients had cold nodule which was cystic in 24 cases. Fine needle aspiration [FNA] and cytology were done in all of the patients. In 4 patients FNA was considered malignant and in 10 patients it was suspicious to malignancy. 9 patients had surgery and 5 had cancer. According to the present study, FNA is the most accurate tool to select the malignant nodules and to decide on the most suitable surgical intervention