ABSTRACT
Reconstructive treatments in dentistry aimed at achieving complete regeneration of destroyed structures both in soft and hard tissues. To date, this goal has been tried to accomplish using various bone grafts, growth factors, and barrier membranes. Stem cells are the most fascinating area of biology today and have been used clinically in the field of medicine to treat many incurable diseases. The English literature indexed in in the MEDLINE/PubMed database was systematically searched and original papers were critically reviewed on this subject, until the second quarter of 2011. Additional papers were obtained by manual searching reference lists of previously published review papers. More than fifty years ago, the first allogenic hematopoietic stem cell was transplanted in patients. However, the promise of other stem cell populations for tissue replacement and repair remains unachieved. When considering cell-based interventions for tissue regeneration, the factors influencing therapeutic success and safety are more complicated than for traditional treatments. So, it is important for dentists to have a brief understanding about the principles and clinical applications of stem cells in tissue engineering field. This article reviews the most recent published data to regenerate dental and periodontal tissues based on scientific principles and provides fundamental information to readers about the different aspects involved in tissue engineering. Ideal combination of cells, scaffolds, and growth factors for tissue engineering may be extended over future years. The findings collected in this literature review show that we are now at a stage in which engineering a complex tissue, such as the periodontium, is no longer an unachievable goal and the next decade will certainly be an exciting time for dental and periodontal research
Subject(s)
Tissue Engineering , Stem Cells , PeriodonticsABSTRACT
Ulcer and pain have been the most complications arised after periodontal surgery. The purpose of this study was to evaluate the healing and analgesic effect of Phenytoin in donor site of free gingival grafts. This study is a randomized clinical trial with 10 patients received free gingival graft and divided in 2 groups. The wound size measured with digimatic caliper. Donor sites rubbed in case group with Phenytoin and with placebo in control group. The wound size measured in 14th and 28[th] days and evaluated in comparision with baseline. Also, the pain level measured via VAS. Statistical analysis was performed using T pair test and wilcoxaon signed ranks. Statistical analysis showed that case group had better healing due to standard diviation in both appointments [a=0.1, p=0.078, and a=0.05, p=0.049, respectively]. Pain Score was lower in patients treated with phenytoin [p=0.18]. Phenytoin is effective in healing of donor site and reduce pain
ABSTRACT
Statement of Problems: Incomplete therapy of periodontal diseases treated with scalling and root planning [SRP] has been resulted in improvement of host- modulated therapy [HMT] as a new method
Purpose: Introducing an adjunctive therapy in addition to SRP in managing of destructive periodontal therapy was the main purpose of this study
Materials and Methods: Fifteen patients suffered from chronic periodontitis were randomly assigned to test and control groups. Treatment consisted of: SRP+ placebo [control group], SRP+ low dose doxycycline [LDD] twice daily for six months [continous LDD], and SRP+LDD twice daily for first and third two months after completion of phase I [cyclic LDD]. Gingival indices including: probing depth [PD], clinical attachment level [CAL], modified gingival index [MGI], and O'leary plaque index were measured and recorded at baseline and at one and six months after the completion of therapy. The data were analyzed using one-way ANOVA and Kruskal-Wallis tests
Results: Probing depth reduction in both of LDD groups were significantly greater than control group [p<0.01]. However, this reduction happened between baseline and follow-up oppointments. In other word, the differences between the 1-and 6-month evaluation were not significant [p=0.25]. Continous LDD regimen showed an additional PD reduction [from 5.40 to 2.06mm] for pockets greater than 5mm in comparison to the other groups
Conclusion: Within the limitation of this study, the results showed that adjunctive continous and cyclic regimen of low-dose doxycycline can improve the clinical efficacy of conventional therapy, even in patients with less than favorable plaque control
ABSTRACT
Aim and Background: periodontal regeneration is one of periodontal treatments goals that a lot of studies have been conducted on it. Guided tissue regeneration technique [GTR], through the inhibition of epithelial cells and gingival connective tissue immigration, cause PDL fibroblasts proliferation at lesion site and also lead to cementum, bone and PDL reconstruction. Despite successful achievements of this technique in human and animal studies, its application in severe lesions such as furcation involvement grade 111 has not been satisfactory. To promote the level of' treatment success, the application of growth factors as agents for the progression of cells proliferation and immigration and the production of extracellular substance has been suggested. The goal of this article was to review these different factors and conducted researches to present a panorama of modern periodontics
Materials and Methods: articles on growth factors application in periodontal lesions regeneration, up to 2003, were collected from Medline and other medical information banks. More over, a lot of specific cases were studied in dentistry journals
Results: it is concluded that the application of different types of growth factors alone or in combination with each other either allogene or autogene, is able to hasten and motivate periodontal lesions regeneration including: intrabony defects and furcation involvements to more advanced cases such as peri implant bone reconstruction. However, their precise application requires more studies
Conclusion: high-level capability of growth factors in the promotion of periodontal treatments consequences has prouided a favourable background for purposeful researches. So as a promising future in periodontal regenerative methods should be expected