ABSTRACT
Photo-onycholysis is a rare complication of tetracyclines. Three clinical subtypes are usually reported. In type I, several nails are often involved and the separated portion of the nail is half-moon-shaped with proximal convexity. In type II, only one nail is involved and there is a proximal notch due to the concentration of ultraviolet rays. Type III is medio-ungueal, away from distal end and lateral folds of the nail. We report a new form of photo-onycholysis induced by doxycycline resembling the latter subtype. In fact there is no involvement of the distal or disto-lateral end of the nail but the separation of the nail starts from the proximal fold. As far as we know, such a clinical feature has not been reported before
Subject(s)
Humans , Female , Photolysis/drug effects , Dermatitis, Photoallergic , Nails/drug effectsABSTRACT
Between January 1991 and Janury 1992, we have collected in National Center of Pharmacovigilance, 3 cases of drug-induced hepatitis in which the responsability of Methyldopa was suspected. In 2 cases, we noticed a mixed hepatitis that associate an intense cytolysis, a cholestase and a hepatocellular insufficiency. Cytolysis, cholestase and hepatoceliular insufficiency evolved favouraby after stopping treatment in all cases. The great delay from treatment start [4 months to 5 years] and the previous hepatitis history in all cases, suggested a toxi mechanism for these drug-induced hepatitis. As Mehtyldopa is still used in many countries for its cheaper cost, we must take care before prescribing it by a good research of hepatic antecedents