ABSTRACT
Background: Urinary tract infections (UTIs) are a major public health problem in terms of morbidity and financial cost in CKD patients in India. The resistance pattern of community acquired uropathogens in CKD patients has not been extensively studied. Thus, knowledge of local antimicrobial susceptibility patterns of common uropathogens is essential for prudent empiric therapy of community acquired UTIs.Methods: It is a cross sectional study conducted in a tertiary care hospital involving 65 chronic kidney disease patients with UTI who attended general medicine OPD and those admitted in wards after fulfilling the inclusion and exclusion criteria, after obtaining written informed consent. Blood sample and urine samples were collected from these patients and sent for blood analysis, urine analysis and urine culture and sensitivity.Results: Among 65 CKD participants with UTI who were studied, E. coli (47.7%) and K. pneumoniae (15.4%) were the most common isolates which were sensitive in order of colistin, polymyxin B, meropenem (carbapenem) and less sensitive to other commonly used antibiotics.Conclusions: The main purpose of this study was to find the various common local uropathogens in CKD patients and their antibiotic profile which will help in formulating antibiotic therapies. As previously stated, there are very few studies regarding profile and management of UTI in CKD patients. Hence this study can throw some light into this area.
ABSTRACT
Background: Lipid abnormalities are common among patients with chronic kidney disease (CKD) and it tends to persist/worsen even after initiating treatment. The cardiovascular mortality and morbidity remains significantly high in this population. The present study was carried out to assess the effect of yoga therapy on fasting lipid profile in CKD patients.Methods: It was an interventional case control study on CKD patients with and without yoga in a tertiary care hospital. About 60 CKD patients aged >18 years were enrolled for the study and were divided into 2 groups of 30 each. Subjects in Group 1 who underwent yoga therapy. Group 2 subjects did not do yoga and they served as controls. Serum lipid profile, RFT and BP were estimated for all patients. Chi-square test, Paired and unpaired t test, mean and delta change were used for comparison. A p-value of <0.05 was considered statistically significant.Results: Out of 60 patients, males were predominant. There was significant reduction in Triglycerides, LDL and VLDL in the yoga group. Total cholesterol also reduced but was not statistically significant. HDL also increased but insignificant statistically.Conclusions: Yoga therapy can be a new added adjuvant and cost effective to the standard lipid lowering agent to reduce the lipid levels in CKD patients.