ABSTRACT
Background: Carbon tetrachloride [CC14] is an industrial solvent that causes liver, kidneys, lungs, testis and brain as well as in blood diseases by generating free radicals. Previous studies on the chemical composition of S. pachycarpa have shown the presence of antioxidant compounds such as flavonoids
Objective: In the present study we investigated protective effects of Sophora pachycarpa extracts on serum level of sex hormones, urea and uric acid in carbon tetrachloride-intoxicated in male rats
Methods: Thirty six male wistar rats [195-200 g] were selected and randomly divided into 6 groups [n=6]: 3 pre-treatment groups received s.pachycarpa extract at doses 50 mg/kg/day, 100 mg/kg/day and 250 mg/kg/day by gavage for 21 days prior to intraperitoneal injection of CC14 500 micro/kg on 21[st] day, control group, CC14 group received 500 micro/kg CC14 on the 21[st] day, post-treatment group received extract at doses 100 mg/kg/day for 10 day at 12h after CCI4 250 micro/kg injection. At the end of the treatment, blood was collected by cardiac puncture from all of the animals and serum levels of sex hormones, urea and uric acid were assessed
Results: Serum levels of follicle stimulating hormone was significantly increased in serum of pre-treatment group III and serum level of luteinizing hormone and testosterone in serum of pre-treatment groups compared to CC14 was significantly increased [P<0.05]
Also serum levels of urea in pre-treatment and post-treatment groups and serum level of uric acid in serum of pre-treatment II and III [100 and 250 mg/kg] was significantly decreased compared to CC14 [P<0.05]
Conclusion: Together, our data suggest that Sophora pachycarpa extract can potentially ameliorate toxic effects of CCI4
ABSTRACT
Conventional risk factors for coronary artery disease and myocardial infarction do not explain all of the clinical and epidemiological features of the disease. Periodontal disease is a common bacterial and destructive disorder of oral tissues. Many studies demonstrate close association between chronic periodontitis and development of generalized inflammation, vascular endothelial injury, and atherosclesis. Periodontal disease has been convincingly emerging as an important independent risk factor for ischemic heart disease. A case - control study was carried out to assess the prevalence of periodontitis in patients with Acute myocardial Infarction [AMI] and evaluate the possible relationship between AMI and chronic periodontitis. A number of 160 patients, aged 35 to 70 years old, enrolled in the study. Eighty patients [43 men, 37 women] were examined four days after hospitalization due to AMI. Control group consisted of 80 persons [38 men, 42 women] with normal coronary angiography. The following periodontal parameters were examined: Plaque index [PI], gingiral index [GI], bleeding on probing [BOP], probing depth [PD], clinical attachment loss [CAL] and number of sites with CAL. The case, compared to control showed significantly worse results for some periodontal variables studied: The mean of PD and PD > 3 mm, CAL, and number of sites with CAL, had worse results compared to control despite similar oral hygiene and frequency of brushing. The confounding factors for the present study were found to be hypertension and diabetes. The association between periodontitis and acute myocardial infarction was significant after adjusting for conventional risk factors for AMI