ABSTRACT
The aim of the present study was to assess the antipyretic activity of Siddha herbo-mineral formulation Surangusa Parpam at the dose level of 15mg/kg and 35mg/kg body weight, orally, in brewer yeast induced fever model Wistar rats. Fever was induced by subcutaneous injection of 10ml/kg of 20% w/v aqueous suspension of brewer’s yeast into the nape of the rat's neck. After eighteen hours feverish animals were treated with Surangusa Parpam 15mg/kg and 35mg/kg body weight, orally, and rectal temperatures were evaluated at 0, 1, 2 and 3 hours post-treatment by inserting a well-lubricated bulb of the clinical thermometer. Surangusa Parpam showed a significant decrease in the elevated body temperature of rats that remained sustained throughout the tested time points from 1 to 3 hours in the used model. 35mg/kg body weight dose level showed significant inhibition of elevated body temperature when compared with the standard control. These results indicate that the Antipyretic activity of Surangusa Parpam and in addition to its well-established anti-inflammatory activity possesses significant antihistamine activity that may be beneficial in symptomatic relief when it is used in the therapy of allergic and inflammatory disorders.
ABSTRACT
Introduction: Stroke is leading cause of death after cardiacdisease and there has been a paradigm shift in the managementof stroke after the advent of intravenous thrombolysis andmechanical thrombectomy. Clinicians are often challengedregarding the outcome as the morbidity and mortality are highif not managed appropriately. As there are various factorswhich influence the mortality in each type of stroke, our studyhas been designed out find the mortality rates and to identifythe factors influencing in each type of stroke.Material and methods: This prospective study was conductedat tertiary care centre for a period of one year among 190patients who presented with acute stroke. All patients wereevaluated by complete medical history, meticulous physicaland neurological examination, necessary blood investigationsand brain imaging. All the patients were categorized intoischemic and haemorrhagic stroke. The outcome of patientswas noted in terms of mortality. Various parameters thatinfluenced the mortality were analysed using statisticalpackage for social sciences and compared.Results: Out of the 190 patients, 151 had ischemic and 39had a haemorrhagic stroke. Regarding the outcome 22.6%died. Elderly patients, patients with stress hyperglycemia anddiabetes, patients with prior history of CVA, raised intracranialtension, low Glascow coma scale, higher BP on admission,altered renal function and presence of nosocomial infectionswere predictors of mortality in both stroke types. Additionallyin ischemic stroke we found that the involvement of more thanone vascular territory of the brain and the presence of atrialfibrillation have higher mortality.Conclusion: Considering these factors with larger sample sizein both tertiary and other care centres we can evolve bettercriteria and guideline in the management of stroke.