ABSTRACT
The Renin-Angiotensin System [RAS] is an important regulator for blood pressure and kidney disease. The level of vaso active peptide Angiotensin-II is mainly determined by the RAS enzyme angiotensin converting enzyme-1 [ACE-1]. To investigate the association of ACE I/D polymorphism and Chronic Kidney Disease [CKD] in south India. In the present study, we have collected CKD patients [n = 147] and control subjects [n = 211] from Tamilnadu. Genotyping was carried out by polymerase chain reaction [PCR] on the basis of allele specific primers. The DD genotype is associated with the female population [OR-CI = 2.40 [1.05-5.51], p = 0.04] as compared to the male population [OR-CI = 0.75 [0.37-1.51], p = 0.42]. Further, we found the over representation of [I] - allele [homozygous II and heterozygous ID] in unaffected males [OR [CI] - 0.58 [0.32-1.04], p = 0.07] which suggests its protective role in male population. The DD genotype of ACE is associated with CKD in south India