Effect of clausena dent at a [WILLD.] M. Roem. against paracetamol induced hepatotoxicity in rats

Ethanol extract of Clausena dentata [Willd.] M. Roem [Rutaceae] was evaluated for hepatoprotective activity in rats. The plant extract [250 mg/kg, p.o.] showed a remarkable hepatoprotective activity against acetaminophen-induced hepatotoxicity as judged from the serum markers for liver damage. Acetaminophen induced a signi-ficant rise in aspartate amino transferase [AST], alanine amino transferase [ALT], alkaline phosphatase [ALP], total bilirubin, gamma glutamate transpeptidase [GGTP] and decrease in total protein. Treatment of rats with ethanol extract [250 mg/kg] significantly [P < 0.001] altered serum marker enzymes levels to near normal against acetaminophen treated rats. The activity of the extract was comparable to the standard drug, silymarin [50 mg/kg, p.o.]. Histopathological changes of liver sample were compared with respective control. Results indicate that Clausena dentata possesses hepatoprotective effect on acetaminophen-induced hepatotoxicity in rats

Antitumor activity of pandanus fascicitlaris Lam. on Dalton's ascitic lymphoma [DAL] in mice

Antitumor activity of ethanol extract of Pandanus fascicularis Lam. [EPF] was studied in mice. The antiturnor activity of EPF was evaluated against Dalton's ascitic lymphoma [DAL] tumor model on dose dependent manner. The activity was assessed using survival time, average increase in body weight, haemalological parameters and solid tumor volume. Oral administration of EPF increased the survival time and decreased the average body weight of the tumor bearing mice. After 14 days of inoculation. EPF is able to reverse the changes in the haematological parameters, protein and PCV consequent to tumor inoculation. Oral administration of EPF was effective in reducing solid tumor mass development induced by DAL cells. The results show that EPF possess significant antitumor activity in dose dependent manner

Effect of aqueous and ethanol extracts of Cassia auriculata L. flowers on diabetes using alloxan induced diabetic rats

In the present study the antidiabetic potential of aqueous and ethanol extract of Cassia auriculata L. flowers was assessed in alloxan-induced diabetic rats. The phytochemical screening and antioxidant activity were made in these extracts. Antidiabetic agents [Flavonoids and phenolic acids] and free radical scavenging activity in water-soluble fraction of the ethanol extract was higher compared to that of aqueous extract. Diabetic rats showed increase in blood glucose [p<0.01] and decrease in plasma insulin [p<0.01] levels after 48 hrs of alloxan administration. The oral administration of water-soluble fraction of the ethanol extract at a dose of 0.25 and 0.5g/kg of body of weight, for 30 days exhibited a significant [p<0.001] reduction in the blood glucose level and a remarkable increase in plasma insulin level compared to the aqueous extract-treated rats and diabetic control. The level of serum triglycerides and total cholesterol were significantly [p<0.01] increased in diabetic rats. The marker enzymes of liver toxicity such as serum alanine transaminase [ALT], serum aspartate transaminase [AST], serum acid phosphatase [ACP], and serum alkaline phosphatase [ALP] were elevated significantly [p<0.01] in diabetic control. The liver glycogen and glycogen synthase levels were also increased significantly [p<0.01] in alloxan-induced diabetic rats. In addition changes in the body weight and food intake were also analyzed in diabetic and the extracts-treated rats. Treatment with water soluble fraction of ethanol extract and aqueous extract of C. auriculata flowers restored the above altered parameters significantly in diabetic animals. The water soluble fraction of the ethanol extract showed a more efficient antihyperglycemic effect compared to the aqueous extract